Relation of fatty acid composition in lead-exposed mallards to fat mobilization, lipid peroxidation and alkaline phosphatase activity

Rafael Mateo, W. Nelson Beyer, James W. Spann, David J. Hoffman

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Abstract

The increase of n-6 polyunsaturated fatty acids (PUFA) in animal tissues has been proposed as a mechanism of lead (Pb) poisoning through lipid peroxidation or altered eicosanoids metabolism. We have studied fatty acid (FA) composition in liver and brain of mallards (Anas platyrhynchos) feeding for 3 weeks on diets containing combinations of low or high levels of vitamin E (20 or 200 UI/kg) and Pb (0 or 2 g/kg). Saturated FA, n-6 PUFA and total concentrations of FA were higher in livers of Pb-exposed mallards, but not in their brains. The percentage of n-6 PUFA in liver and brain was slightly higher in Pb-exposed mallards. The increase of n-6 PUFA in liver was associated with decreased triglycerides and increased cholesterol in plasma, thus could be in part attributed to feed refusal and fat mobilization. The hepatic ratios between adrenic acid (22:4 n-6) and arachidonic acid (20:4 n-6) or between adrenic acid and linoleic acid (18:2 n-6) were higher in Pb exposed birds, supporting the existing hypothesis of increased fatty acid elongation by Pb. Among the possible consequences of increased n-6 PUFA concentration in tissues, we found increased lipid peroxidation in liver without important histopathological changes, and decreased plasma alkaline phosphatase activity that may reflect altered bone metabolism in birds. © 2003 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)451-458
JournalComparative Biochemistry and Physiology - C Toxicology and Pharmacology
Volume135
Issue number4
DOIs
Publication statusPublished - 1 Aug 2003

Keywords

  • Alkaline phosphatase
  • Anorexia
  • Arachidonic acid
  • Fatty acids
  • Heavy metals
  • Lead
  • Plasma lipids
  • TBARS

Fingerprint Dive into the research topics of 'Relation of fatty acid composition in lead-exposed mallards to fat mobilization, lipid peroxidation and alkaline phosphatase activity'. Together they form a unique fingerprint.

Cite this