Relation between amino acid composition and cellular location of proteins

Juan Cedano, Patrick Aloy, Josep A. Perez-Pons, Enrique Querol

Research output: Contribution to journalArticleResearchpeer-review

363 Citations (Scopus)

Abstract

A correlation analysis of the amino acid composition and the cellular location of a protein is presented. The statistical analysis discriminates among the following five protein classes: integral membrane proteins, anchored membrane proteins, extracellular proteins, intracellular proteins and nuclear proteins. This segregation into protein classes related to their location can help researchers to design experimental work for testing hypotheses in order to find out the functionality of a reading frame in search of function. A program (ProtLock) to predict the cellular location of a protein has been designed.
Original languageEnglish
Pages (from-to)594-600
JournalJournal of Molecular Biology
Volume266
DOIs
Publication statusPublished - 28 Feb 1997

Keywords

  • Amino acid composition
  • Biocomputing
  • Protein location
  • Protein prediction algorithms
  • Protein sequence analysis

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