Relapse risk after autologous stem cell transplantation in patients with lymphoma based on CD34+ cell dose

Marc Sorigue, Juan Manuel Sancho, Mireia Morgades, Miriam Moreno, Juan Ramon Grífols, Eva Alonso, Jordi Juncà, Christelle Ferrà, Montserrat Batlle, Susana Vives, Cristina Motlló, Montserrat García-Caro, Jose Tomás Navarro, Fuensanta Millà, Evarist Feliu, Josep María Ribera

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4 Citations (Scopus)

Abstract

© 2016 Informa UK Limited, trading as Taylor & Francis Group. It is unclear whether higher CD34 + cell doses infused for ASCT have any influence on survival or relapse in patients with lymphoma. We analyzed the correlation of infused CD34 + cell dose with relapse, survival, and hematopoietic recovery in 146 consecutive patients undergoing ASCT for lymphoma. Higher doses (>5 × 10 6 /kg) were significantly correlated with earlier hematopoietic recovery, fewer infectious episodes, lower transfusion needs. No differences were observed in lymphoma outcomes (4-year relapse incidence of 38% [95%CI: 29%–48%] in the lower dose group versus 51% [95%CI: 30%–69%] in the higher dose group, 10-year OS probabilities of 58% [95%CI: 48%–68%] versus 75% [95%CI: 59%–91%], 10-year DFS probabilities of 47% [95%CI: 37%–57%] versus 42% [95%CI: 23%–61%], p = NS for all outcomes). In this series, a higher infused CD34 + cell dose did not correlate with survival or relapse but correlated with earlier hematopoietic recovery and lower resource consumption.
Original languageEnglish
Pages (from-to)916-922
JournalLeukemia and Lymphoma
Volume58
Issue number4
DOIs
Publication statusPublished - 3 Apr 2017

Keywords

  • Autologous stem cell transplantation
  • hematopoietic recovery
  • lymphoma
  • relapse
  • resource use
  • survival

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    Sorigue, M., Sancho, J. M., Morgades, M., Moreno, M., Grífols, J. R., Alonso, E., Juncà, J., Ferrà, C., Batlle, M., Vives, S., Motlló, C., García-Caro, M., Navarro, J. T., Millà, F., Feliu, E., & Ribera, J. M. (2017). Relapse risk after autologous stem cell transplantation in patients with lymphoma based on CD34+ cell dose. Leukemia and Lymphoma, 58(4), 916-922. https://doi.org/10.1080/10428194.2016.1222378