Regulatory T cells, maternal-foetal immune tolerance and recurrent miscarriage: New therapeutic challenging opportunities

Jaume Alijotas-Reig; Taisiia Melnychuk; Josep Maria Gris

doi:10.1016/j.medcli.2014.01.033

Regulatory T cells, maternal-foetal immune tolerance and recurrent miscarriage: New therapeutic challenging opportunities

Jaume Alijotas-Reig, Taisiia Melnychuk, Josep Maria Gris

Department of Medicine

Research output: Contribution to journal › Review article › Research › peer-review

15 Citations (Scopus)

Abstract

© 2014 Elsevier España, S.L.U. All rights reserved. Because maternal alloreactive lymphocytes are not depleted during pregnancy, local and/or systemic mechanisms have to play a key role in altering the maternal immune response. Peripheral T regulatory cells (pTregs) at the maternal-foetal interface are necessary in situ to prevent early abortion, but only those pTregs that have been previously exposed to paternal alloantigens. It has been showed that pregnancy selectively stimulates the accumulation of maternal Foxp3+CD4+CD25+ (Foxp3Tregs) cells with foetal specificity. Interestingly, after delivery, foetal-specific pTregs persist at elevated levels, maintain tolerance to pre-existing foetal antigen, and rapidly re-accumulate during subsequent pregnancy. pTreg up-regulation could be hypothesized as a possible future therapeutic strategy in humans.

Original language	English
Pages (from-to)	265-268
Journal	Medicina Clinica
Volume	144
Issue number	6
DOIs	https://doi.org/10.1016/j.medcli.2014.01.033
Publication status	Published - 1 Jan 2015

Keywords

Cytokines
Implantation failure
Maternal-foetal tolerance
Miscarriages
NK cells/KIR
Regulatory-T lymphocytes
Treatment

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10.1016/j.medcli.2014.01.033

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title = "Regulatory T cells, maternal-foetal immune tolerance and recurrent miscarriage: New therapeutic challenging opportunities",

abstract = "{\textcopyright} 2014 Elsevier Espa{\~n}a, S.L.U. All rights reserved. Because maternal alloreactive lymphocytes are not depleted during pregnancy, local and/or systemic mechanisms have to play a key role in altering the maternal immune response. Peripheral T regulatory cells (pTregs) at the maternal-foetal interface are necessary in situ to prevent early abortion, but only those pTregs that have been previously exposed to paternal alloantigens. It has been showed that pregnancy selectively stimulates the accumulation of maternal Foxp3+CD4+CD25+ (Foxp3Tregs) cells with foetal specificity. Interestingly, after delivery, foetal-specific pTregs persist at elevated levels, maintain tolerance to pre-existing foetal antigen, and rapidly re-accumulate during subsequent pregnancy. pTreg up-regulation could be hypothesized as a possible future therapeutic strategy in humans.",

keywords = "Cytokines, Implantation failure, Maternal-foetal tolerance, Miscarriages, NK cells/KIR, Regulatory-T lymphocytes, Treatment",

author = "Jaume Alijotas-Reig and Taisiia Melnychuk and Gris, {Josep Maria}",

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TY - JOUR

T1 - Regulatory T cells, maternal-foetal immune tolerance and recurrent miscarriage: New therapeutic challenging opportunities

AU - Alijotas-Reig, Jaume

AU - Melnychuk, Taisiia

AU - Gris, Josep Maria

PY - 2015/1/1

Y1 - 2015/1/1

N2 - © 2014 Elsevier España, S.L.U. All rights reserved. Because maternal alloreactive lymphocytes are not depleted during pregnancy, local and/or systemic mechanisms have to play a key role in altering the maternal immune response. Peripheral T regulatory cells (pTregs) at the maternal-foetal interface are necessary in situ to prevent early abortion, but only those pTregs that have been previously exposed to paternal alloantigens. It has been showed that pregnancy selectively stimulates the accumulation of maternal Foxp3+CD4+CD25+ (Foxp3Tregs) cells with foetal specificity. Interestingly, after delivery, foetal-specific pTregs persist at elevated levels, maintain tolerance to pre-existing foetal antigen, and rapidly re-accumulate during subsequent pregnancy. pTreg up-regulation could be hypothesized as a possible future therapeutic strategy in humans.

AB - © 2014 Elsevier España, S.L.U. All rights reserved. Because maternal alloreactive lymphocytes are not depleted during pregnancy, local and/or systemic mechanisms have to play a key role in altering the maternal immune response. Peripheral T regulatory cells (pTregs) at the maternal-foetal interface are necessary in situ to prevent early abortion, but only those pTregs that have been previously exposed to paternal alloantigens. It has been showed that pregnancy selectively stimulates the accumulation of maternal Foxp3+CD4+CD25+ (Foxp3Tregs) cells with foetal specificity. Interestingly, after delivery, foetal-specific pTregs persist at elevated levels, maintain tolerance to pre-existing foetal antigen, and rapidly re-accumulate during subsequent pregnancy. pTreg up-regulation could be hypothesized as a possible future therapeutic strategy in humans.

KW - Cytokines

KW - Implantation failure

KW - Maternal-foetal tolerance

KW - Miscarriages

KW - NK cells/KIR

KW - Regulatory-T lymphocytes

KW - Treatment

U2 - 10.1016/j.medcli.2014.01.033

DO - 10.1016/j.medcli.2014.01.033

M3 - Review article

SN - 0025-7753

VL - 144

SP - 265

EP - 268

JO - Medicina Clinica

JF - Medicina Clinica

IS - 6

ER -

Regulatory T cells, maternal-foetal immune tolerance and recurrent miscarriage: New therapeutic challenging opportunities

Abstract

Keywords

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