Regulatory T cells, maternal-foetal immune tolerance and recurrent miscarriage: New therapeutic challenging opportunities

Jaume Alijotas-Reig, Taisiia Melnychuk, Josep Maria Gris

Research output: Contribution to journalReview articleResearchpeer-review

14 Citations (Scopus)

Abstract

© 2014 Elsevier España, S.L.U. All rights reserved. Because maternal alloreactive lymphocytes are not depleted during pregnancy, local and/or systemic mechanisms have to play a key role in altering the maternal immune response. Peripheral T regulatory cells (pTregs) at the maternal-foetal interface are necessary in situ to prevent early abortion, but only those pTregs that have been previously exposed to paternal alloantigens. It has been showed that pregnancy selectively stimulates the accumulation of maternal Foxp3+CD4+CD25+ (Foxp3Tregs) cells with foetal specificity. Interestingly, after delivery, foetal-specific pTregs persist at elevated levels, maintain tolerance to pre-existing foetal antigen, and rapidly re-accumulate during subsequent pregnancy. pTreg up-regulation could be hypothesized as a possible future therapeutic strategy in humans.
Original languageEnglish
Pages (from-to)265-268
JournalMedicina Clinica
Volume144
Issue number6
DOIs
Publication statusPublished - 1 Jan 2015

Keywords

  • Cytokines
  • Implantation failure
  • Maternal-foetal tolerance
  • Miscarriages
  • NK cells/KIR
  • Regulatory-T lymphocytes
  • Treatment

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