Regulatory T cells in type 1 diabetic patients with autoimmune chronic atrophic gastritis

Núria Alonso, María Jesús Martínez-Arconada, María Luisa Granada, Berta Soldevila, Ana Cantón, José Luis Mate, Anna Sanmartí, Eva María Martínez-Cáceres

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12 Citations (Scopus)

Abstract

Type A chronic atrophic gastritis (CAG) is increased in type 1 diabetic patients (DM1). To address this issue, we determined and analyzed the number of peripheral blood regulatory T cells (Tregs) in 15 DM1-CAG patients, 15 DM1 patients without associated autoantibodies (DM1) and 15 healthy controls by flow cytometry and compared gastric Tregs expression (CD4+Foxp3+/CD4+) in DM1-CAG patients with that observed in 10 control Helicobacter pylori CAG-infected biopsies. The percentage of peripheral Tregs was higher in DM1-CAG patients compared to DM1 and controls (CD4+Foxp3+: 7.67 ± 1.91% vs. 5.38 ± 1.57% and 5.65 ± 1.76%, P < 0.001, respectively), with no differences between DM1 and controls. Gastric mucosal Tregs were higher in H. pylori CAG than in DM1-CAG patients (31.31 ± 5.52% vs. 7.68 ± 3.70%; P < 0.001). Data suggest that Tregs are stimulated in patients with more than one autoimmune disease (DM1 + CAG) in an ineffectual attempt to control autoimmune response and that the number of Tregs in gastric mucosa implicated in the chronification of gastritis differs according to the etiology. © 2009 Humana Press.
Original languageEnglish
Pages (from-to)420-428
JournalEndocrine
Volume35
Issue number3
DOIs
Publication statusPublished - 1 Jun 2009

Keywords

  • Gastrin
  • Gastritis
  • Parietal cell antibodies
  • Pepsinogen I
  • Regulatory T cells
  • Type 1 diabetes mellitus

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