Regulation of adipose tissue inflammation by interleukin 6

Myoung Sook Han, Alexis White, Rachel J. Perry, Joao Paulo Camporez, Juan Hidalgo, Gerald I. Shulman, Roger J. Davis*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Abstract

Obesity is associated with a chronic state of low-grade inflammation and progressive tissue infiltration by immune cells and increased expression of inflammatory cytokines. It is established that interleukin 6 (IL6) regulates multiple aspects of metabolism, including glucose disposal, lipolysis, oxidative metabolism, and energy expenditure. IL6 is secreted by many tissues, but the role of individual cell types is unclear. We tested the role of specific cells using a mouse model with conditional expression of the Il6 gene. We found that IL6 derived from adipocytes increased, while IL6 derived from myeloid cells and muscle suppressed, macrophage infiltration of adipose tissue. These opposite actions were associated with a switch of IL6 signaling from a canonical mode (myeloid cells) to a noncanonical trans-signaling mode (adipocytes and muscle) with increased expression of the ADAM10/17 metalloprotease that promotes trans-signaling by the soluble IL6 receptor α. Collectively, these data demonstrate that the source of IL6 production plays a major role in the physiological regulation of metabolism.

Original languageAmerican English
Pages (from-to)2751-2760
Number of pages10
JournalProceedings of the National Academy of Sciences of the United States of America
Volume117
Issue number6
DOIs
Publication statusPublished - 11 Feb 2020

Keywords

  • Adipose tissue
  • Inflammation
  • Insulin resistance
  • Interleukin 6

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