Refractoriness to rituximab-based therapy and elevated serum B2-microglobulin predict for inferior survival in marginal zone lymphoma

Marc Sorigue, Mark Bishton, Eva Domingo-Domenech, Andrew McMillan, Roosa Prusila, Olga García, Milla Kuusisto, Maria Condom, Gustavo Tapia, Josep María Ribera, Outi Kuittinen, Christopher P. Fox, Juan Manuel Sancho

Research output: Contribution to journalArticleResearch

Abstract

© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Short responses to immunochemotherapy predict for an inferior OS in follicular lymphoma. We set out to determine whether this is also the case in marginal zone lymphoma. A group of 139 marginal zone lymphoma (MZL) patients treated with front-line immuno- or immunochemotherapy (I/ICT) were categorized into I/ICT-refractory (non-response or relapse/progression within six months of treatment response assessment) or I/ICT-sensitive. Twenty-three patients (17%) were refractory. Refractory patients had inferior OS (4-yr probabilities of 57% vs. 83%, p =.0003) as did those with beta2-microglobulin (B2M)>3 mg/L (4-yr probabilities of 80% vs. 100%, p =.0029). On multivariable analysis they both showed a borderline significant correlation with OS (p =.06 and.07, respectively). B2M > 3 mg/L was also an adverse prognostic factor for progression-free survival in both univariable (4-yr probability of 61% vs. 83%, p =.02) and multivariable analysis (HR 2.9, p =.02). In conclusion, B2M and refractoriness to I/ICT may identify patients with MZL at higher risk of inferior survival.
Original languageEnglish
Pages (from-to)2524-2531
JournalLeukemia and Lymphoma
Volume60
DOIs
Publication statusPublished - 24 Aug 2019

Keywords

  • beta-2 microglobulin
  • bone marrow involvement
  • immunochemotherapy
  • Marginal zone lymphoma
  • prognosis
  • refractoriness
  • survival
  • transformation

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