Reduction of piperidinoisoxazolidines: Competitive cyclisation to indolizidines or epoxides

Ramón Alibés; Félix Busqué; Pedro De March; Marta Figueredo; Josep Font

doi:10.1016/S0040-4020(98)00677-2

Reduction of piperidinoisoxazolidines: Competitive cyclisation to indolizidines or epoxides

Ramón Alibés, Félix Busqué, Pedro De March, Marta Figueredo, Josep Font

Department of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

11 Citations (Scopus)

Abstract

In the reduction of polysubstituted piperidinoisoxazolidines, we have observed two competitive cyclisation pathways, leading to either indolizidines or epoxides. The yields of indolizidines can be optimised by an appropriate choice of the reducing agent and through a careful control of the work-up conditions.

Original language	English
Pages (from-to)	11581-11588
Journal	Tetrahedron
Volume	54
Issue number	38
DOIs	https://doi.org/10.1016/S0040-4020(98)00677-2
Publication status	Published - 17 Sept 1998

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title = "Reduction of piperidinoisoxazolidines: Competitive cyclisation to indolizidines or epoxides",

abstract = "In the reduction of polysubstituted piperidinoisoxazolidines, we have observed two competitive cyclisation pathways, leading to either indolizidines or epoxides. The yields of indolizidines can be optimised by an appropriate choice of the reducing agent and through a careful control of the work-up conditions.",

author = "Ram{\'o}n Alib{\'e}s and F{\'e}lix Busqu{\'e} and {De March}, Pedro and Marta Figueredo and Josep Font",

year = "1998",

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T1 - Reduction of piperidinoisoxazolidines: Competitive cyclisation to indolizidines or epoxides

AU - Alibés, Ramón

AU - Busqué, Félix

AU - De March, Pedro

AU - Figueredo, Marta

AU - Font, Josep

PY - 1998/9/17

Y1 - 1998/9/17

N2 - In the reduction of polysubstituted piperidinoisoxazolidines, we have observed two competitive cyclisation pathways, leading to either indolizidines or epoxides. The yields of indolizidines can be optimised by an appropriate choice of the reducing agent and through a careful control of the work-up conditions.

AB - In the reduction of polysubstituted piperidinoisoxazolidines, we have observed two competitive cyclisation pathways, leading to either indolizidines or epoxides. The yields of indolizidines can be optimised by an appropriate choice of the reducing agent and through a careful control of the work-up conditions.

U2 - 10.1016/S0040-4020(98)00677-2

DO - 10.1016/S0040-4020(98)00677-2

M3 - Article

SN - 0040-4020

VL - 54

SP - 11581

EP - 11588

JO - Tetrahedron

JF - Tetrahedron

IS - 38

ER -

Reduction of piperidinoisoxazolidines: Competitive cyclisation to indolizidines or epoxides

Abstract

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