Red blood cell transfusion-transmitted acute hepatitis E in an immunocompetent subject in Europe: a case report

Mar Riveiro-Barciela; Silvia Sauleda; Josep Quer; Fernando Salvador; Josep Gregori; María Pirón; Francisco Rodríguez-Frías; Maria Buti

doi:10.1111/trf.13876

Red blood cell transfusion-transmitted acute hepatitis E in an immunocompetent subject in Europe: a case report

Mar Riveiro-Barciela, Silvia Sauleda, Josep Quer, Fernando Salvador, Josep Gregori, María Pirón, Francisco Rodríguez-Frías, Maria Buti

Department of Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › Research › peer-review

21 Citations (Scopus)

Abstract

© 2016 AABB BACKGROUND: Acute hepatitis E in industrialized countries is usually related to intake or manipulation of undercooked or raw meat. Cases of transfusion-transmitted hepatitis E have rarely been documented in immunosuppressed patients, mainly after receiving frozen plasma. STUDY DESIGN AND METHODS: A 61-year-old man was admitted to hospital for jaundice. His personal history included disseminated bacillus Calmette-Guerin infection treated with antituberculous drugs. He had received red blood cell (RBC) transfusion 2 months previously, during admission for mycotic aneurysm surgery. Since liver function tests worsened despite stopping antituberculous drugs, other causes of acute hepatitis were explored. RESULTS: Acute hepatitis E was diagnosed by the presence of both immunoglobulin M and hepatitis E virus (HEV) RNA. Traceback procedure for the 8 RBC units was carried out, and one of the eight archive plasma samples tested positive for HEV RNA, with an estimated viral load of 75,000 IU/mL. Phylogenetic analysis revealed the same HEV strain Genotype 3 in one of the transfused RBC products and in the patient's serum sample. CONCLUSION: Transfusion of RBCs with detectable HEV RNA is a risk factor for acute hepatitis E in immunocompetent patients in Europe.

Original language	English
Pages (from-to)	244-247
Journal	Transfusion
Volume	57
Issue number	2
DOIs	https://doi.org/10.1111/trf.13876
Publication status	Published - 1 Feb 2017

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title = "Red blood cell transfusion-transmitted acute hepatitis E in an immunocompetent subject in Europe: a case report",

abstract = "{\textcopyright} 2016 AABB BACKGROUND: Acute hepatitis E in industrialized countries is usually related to intake or manipulation of undercooked or raw meat. Cases of transfusion-transmitted hepatitis E have rarely been documented in immunosuppressed patients, mainly after receiving frozen plasma. STUDY DESIGN AND METHODS: A 61-year-old man was admitted to hospital for jaundice. His personal history included disseminated bacillus Calmette-Guerin infection treated with antituberculous drugs. He had received red blood cell (RBC) transfusion 2 months previously, during admission for mycotic aneurysm surgery. Since liver function tests worsened despite stopping antituberculous drugs, other causes of acute hepatitis were explored. RESULTS: Acute hepatitis E was diagnosed by the presence of both immunoglobulin M and hepatitis E virus (HEV) RNA. Traceback procedure for the 8 RBC units was carried out, and one of the eight archive plasma samples tested positive for HEV RNA, with an estimated viral load of 75,000 IU/mL. Phylogenetic analysis revealed the same HEV strain Genotype 3 in one of the transfused RBC products and in the patient's serum sample. CONCLUSION: Transfusion of RBCs with detectable HEV RNA is a risk factor for acute hepatitis E in immunocompetent patients in Europe.",

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Red blood cell transfusion-transmitted acute hepatitis E in an immunocompetent subject in Europe: a case report. / Riveiro-Barciela, Mar; Sauleda, Silvia; Quer, Josep; Salvador, Fernando; Gregori, Josep; Pirón, María; Rodríguez-Frías, Francisco ; Buti, Maria.

In: Transfusion, Vol. 57, No. 2, 01.02.2017, p. 244-247.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Red blood cell transfusion-transmitted acute hepatitis E in an immunocompetent subject in Europe: a case report

AU - Riveiro-Barciela, Mar

AU - Sauleda, Silvia

AU - Quer, Josep

AU - Salvador, Fernando

AU - Gregori, Josep

AU - Pirón, María

AU - Rodríguez-Frías, Francisco

AU - Buti, Maria

PY - 2017/2/1

Y1 - 2017/2/1

N2 - © 2016 AABB BACKGROUND: Acute hepatitis E in industrialized countries is usually related to intake or manipulation of undercooked or raw meat. Cases of transfusion-transmitted hepatitis E have rarely been documented in immunosuppressed patients, mainly after receiving frozen plasma. STUDY DESIGN AND METHODS: A 61-year-old man was admitted to hospital for jaundice. His personal history included disseminated bacillus Calmette-Guerin infection treated with antituberculous drugs. He had received red blood cell (RBC) transfusion 2 months previously, during admission for mycotic aneurysm surgery. Since liver function tests worsened despite stopping antituberculous drugs, other causes of acute hepatitis were explored. RESULTS: Acute hepatitis E was diagnosed by the presence of both immunoglobulin M and hepatitis E virus (HEV) RNA. Traceback procedure for the 8 RBC units was carried out, and one of the eight archive plasma samples tested positive for HEV RNA, with an estimated viral load of 75,000 IU/mL. Phylogenetic analysis revealed the same HEV strain Genotype 3 in one of the transfused RBC products and in the patient's serum sample. CONCLUSION: Transfusion of RBCs with detectable HEV RNA is a risk factor for acute hepatitis E in immunocompetent patients in Europe.

AB - © 2016 AABB BACKGROUND: Acute hepatitis E in industrialized countries is usually related to intake or manipulation of undercooked or raw meat. Cases of transfusion-transmitted hepatitis E have rarely been documented in immunosuppressed patients, mainly after receiving frozen plasma. STUDY DESIGN AND METHODS: A 61-year-old man was admitted to hospital for jaundice. His personal history included disseminated bacillus Calmette-Guerin infection treated with antituberculous drugs. He had received red blood cell (RBC) transfusion 2 months previously, during admission for mycotic aneurysm surgery. Since liver function tests worsened despite stopping antituberculous drugs, other causes of acute hepatitis were explored. RESULTS: Acute hepatitis E was diagnosed by the presence of both immunoglobulin M and hepatitis E virus (HEV) RNA. Traceback procedure for the 8 RBC units was carried out, and one of the eight archive plasma samples tested positive for HEV RNA, with an estimated viral load of 75,000 IU/mL. Phylogenetic analysis revealed the same HEV strain Genotype 3 in one of the transfused RBC products and in the patient's serum sample. CONCLUSION: Transfusion of RBCs with detectable HEV RNA is a risk factor for acute hepatitis E in immunocompetent patients in Europe.

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