Red blood cell transfusion-transmitted acute hepatitis E in an immunocompetent subject in Europe: a case report

Mar Riveiro-Barciela, Silvia Sauleda, Josep Quer, Fernando Salvador, Josep Gregori, María Pirón, Francisco Rodríguez-Frías, Maria Buti

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21 Citations (Scopus)

Abstract

© 2016 AABB BACKGROUND: Acute hepatitis E in industrialized countries is usually related to intake or manipulation of undercooked or raw meat. Cases of transfusion-transmitted hepatitis E have rarely been documented in immunosuppressed patients, mainly after receiving frozen plasma. STUDY DESIGN AND METHODS: A 61-year-old man was admitted to hospital for jaundice. His personal history included disseminated bacillus Calmette-Guerin infection treated with antituberculous drugs. He had received red blood cell (RBC) transfusion 2 months previously, during admission for mycotic aneurysm surgery. Since liver function tests worsened despite stopping antituberculous drugs, other causes of acute hepatitis were explored. RESULTS: Acute hepatitis E was diagnosed by the presence of both immunoglobulin M and hepatitis E virus (HEV) RNA. Traceback procedure for the 8 RBC units was carried out, and one of the eight archive plasma samples tested positive for HEV RNA, with an estimated viral load of 75,000 IU/mL. Phylogenetic analysis revealed the same HEV strain Genotype 3 in one of the transfused RBC products and in the patient's serum sample. CONCLUSION: Transfusion of RBCs with detectable HEV RNA is a risk factor for acute hepatitis E in immunocompetent patients in Europe.
Original languageEnglish
Pages (from-to)244-247
JournalTransfusion
Volume57
Issue number2
DOIs
Publication statusPublished - 1 Feb 2017

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