Recurrent pericarditis: Relief with colchicine

J. Guindo, A. Rodriguez de la Serna, J. Ramio, M. A. De Miguel Diaz, M. T. Subirana, M. J. Perez Ayuso, J. Cosin, A. Bayes de Luna

Research output: Contribution to journalArticleResearchpeer-review

100 Citations (Scopus)

Abstract

Recurrence is one of the major complications of pericarditis. Treatment of recurrence is often difficult, and immunosupressive drugs or surgery may be necessary. We conducted an open-label prospective study of nine patients (seven men and two women; age, 18-64 years; mean age, 41.7±13.7 years). Patients were treated with colchicine (1 mg/day) to prevent recurrences. All patients had suffered at least three relapses despite treatment with acetylsalicylic acid, indomethacin, prednisone, or a combination. Pericarditis was classified as idiopathic in five patients, postpericardiotomy in two, post-myocardial infarction in one, and associated with disseminated lupus erythematosus in one. For statistical analysis, we conducted a paired comparison design (Student's t test). All patients treated with colchicine responded favorably to therapy. Prednisone was discontinued in all patients after 2-6 weeks (mean, 26.33±10.9 days), and colchicine alone was continued. After a mean follow-up of 24.3 months (minimum, 10 months; maximum, 54 months), no recurrences were observed in any patient; there was a significant difference between the symptom-free periods before and after treatment with colchicine (p<0.002). Our study suggests that colchicine may be useful in avoiding recurrence of pericarditis, although these results need to be confirmed in a larger, double-blind study.
Original languageEnglish
Pages (from-to)1117-1120
JournalCirculation (New York, N.Y.)
Volume82
Issue number4
DOIs
Publication statusPublished - 1 Jan 1990

Fingerprint Dive into the research topics of 'Recurrent pericarditis: Relief with colchicine'. Together they form a unique fingerprint.

Cite this