Recommendations of the Spanish Antibiogram Committee (COESANT) for selecting antimicrobial agents and concentrations for in vitro susceptibility studies using automated systems

Rafael Cantón, Antonio Oliver, Juan Ignacio Alós, Natividad de Benito, Germán Bou, José Campos, Jorge Calvo, Andrés Canut, Javier Castillo, Emilia Cercenado, Maria Ángeles Domínguez, Felipe Fernández-Cuenca, Jesús Guinea, Nieves Larrosa, Josefina Liñares, Lorena López-Cerero, Antonio López-Navas, Francesc Marco, Beatriz Mirelis, Miguel Ángel Moreno-RomoMaría Isabel Morosini, Ferran Navarro, Jesús Oteo, Álvaro Pascual, Emilio Pérez-Trallero, María Pérez-Vázquez, Alex Soriano, Carmen Torres, Jordi Vila, Luis Martínez-Martínez

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Abstract

© 2019 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica Automated antimicrobial susceptibility testing devices are widely implemented in clinical microbiology laboratories in Spain, mainly using EUCAST (European Committee on Antimicrobial Susceptibility Testing) breakpoints. In 2007, a group of experts published recommendations for including antimicrobial agents and selecting concentrations in these systems. Under the patronage of the Spanish Antibiogram Committee (Comité Español del Antibiograma, COESANT) and the Study Group on Mechanisms of Action and Resistance to Antimicrobial Agents (GEMARA) from the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), and aligned with the Spanish National Plan against Antimicrobial Resistance (PRAN), a group of experts have updated this document. The main modifications from the previous version comprise the inclusion of new antimicrobial agents, adaptation of the ranges of concentrations to cover the EUCAST breakpoints and epidemiological cut-off values (ECOFFs), and the inference of new resistance mechanisms. This proposal should be considered by different manufacturers and users when designing new panels or cards. In addition, recommendations for selective reporting are also included. With this approach, the implementation of EUCAST breakpoints will be easier, increasing the quality of antimicrobial susceptibility testing data and their microbiological interpretation. It will also benefit epidemiological surveillance studies as well as the clinical use of antimicrobials aligned with antimicrobial stewardship programs.
Original languageEnglish
JournalEnfermedades Infecciosas y Microbiologia Clinica
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • Antibiogram
  • Automated susceptibility testing systems
  • MICs
  • Minimum antimicrobial concentrations

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    Cantón, R., Oliver, A., Alós, J. I., de Benito, N., Bou, G., Campos, J., Calvo, J., Canut, A., Castillo, J., Cercenado, E., Domínguez, M. Á., Fernández-Cuenca, F., Guinea, J., Larrosa, N., Liñares, J., López-Cerero, L., López-Navas, A., Marco, F., Mirelis, B., ... Martínez-Martínez, L. (2019). Recommendations of the Spanish Antibiogram Committee (COESANT) for selecting antimicrobial agents and concentrations for in vitro susceptibility studies using automated systems. Enfermedades Infecciosas y Microbiologia Clinica. https://doi.org/10.1016/j.eimc.2019.01.017