TY - JOUR
T1 - Recomendaciones para la selección de antimicrobianos en el estudio de la sensibilidad in vitro con sistemas automáticos y semiautomáticos
AU - Baquero, Fernando
AU - Rodríguez-Baño, Jesús
AU - Mirelis, Beatriz
AU - Cercenado, Emilia
AU - Marco, Francesc
AU - Martínez-Martínez, Luis
AU - Cobo, Javier
AU - Fariñas, María C.
AU - Loza, Elena
AU - García-Sánchez, José Elías
AU - Pérez-Trallero, Emilio
AU - Trujillano, Ignacio
AU - Calvo, Jorge
AU - Domínguez, M. Ángeles
AU - López-Cerezo, Lorena
AU - Vila, Jordi
AU - Torres, Carmen
AU - Oliver, Antonio
AU - Soriano, Francisco
AU - Liñares, Josefina
AU - Prats, Guillermo
AU - Salavert, Miguel
AU - Navarro, Ferran
AU - Campos, José
AU - Castillo, Javier
AU - Alós, Juan Ignacio
AU - Cantón, Rafael
AU - Morosini, María Isabel
AU - Tubau, Fe
AU - Oteo, Jesús
AU - Sáez-Nieto, Juan Antonio
N1 - Funding Information:
7. MENSURA. Recomendaciones del grupo MENSURA para la selección de an-timicrobianos para el estudio de sensibilidad y criterios de interpretación del antibiograma. Rev Esp Quimioter. 2000;13:73-86.
Funding Information:
Hasta la fecha no existe un documento de consenso en España que recoja los criterios por los cuales un antibióti-co deba incluirse en un panel de sensibilidad ni que indi-que las concentraciones más adecuadas para realizar este estudio. Con el objetivo principal de realizar un documen-to de este tipo, el grupo GEMARA junto con el grupo MENSURA (Mesa Española de la Normalización de la Sensibilidad y Resistencia a los Antimicrobianos) reunió a un grupo de expertos en técnicas de sensibilidad, mecanis-mos de resistencia y lectura interpretada del antibiograma. El borrador de dicho documento se presentó en la asamblea del grupo GEMARA durante el XII Congreso de la Socie-dad Española de Enfermedades Infecciosas y Microbiología Clínica (SEIMC) celebrado en Valencia (10-13 de mayo de 2006), fue ratificado por el grupo MENSURA y se expuso, sin limitaciones de acceso, en la página web de la SEIMC (http://www.seimc.org/gemara/ dcsnso.htm) para posibles aportaciones no contempladas en la fases anteriores de discusión. Así mismo, en las primeras reuniones, repre-sentantes de los departamentos técnicos de las casas co-merciales con mayor implantación en España en la comer-cialización de sistemas automáticos para estudio de sensibilidad (BD, Sistema Phoenix; BioMérieux, sistema Vitek2; Dade Boheringer, Sistema MicroScan; Francisco Soria Melguizo, Sistema Wider; e Izasa, Sistema Sensiti-tre) aportaron sus puntos de vista para la elaboración de este documento.
PY - 2007/6/1
Y1 - 2007/6/1
N2 - The number of clinical microbiology laboratories that have incorporated automatic susceptibility testing devices has increased in recent years. The majority of these systems determine MIC values using microdilution panels or specific cards, with grouping into clinical categories (susceptible, intermediate or resistant) and incorporate expert systems to infer resistance mechanisms. This document presents the recommendations of a group of experts designated by Grupo de Estudio de los Mecanismos de Acción y Resistencia a los Antimicrobianos (GEMARA, Study group on mechanisms of action and resistance to antimicrobial agents) and Mesa Española de Normalización de la Sensibilidad y Resistencia a los Antimicrobianos (MENSURA, Spanish Group for Normalizing Antimicrobial Susceptibility and Antimicrobial Resistance), with the aim of including antimicrobial agents and selecting concentrations for the susceptibility testing panels of automatic systems. The following have been defined: various antimicrobial categories (A: must be included in the study panel; B: inclusion is recommended; and C: inclusion is secondary, but may facilitate interpretative reading of the antibiogram) and groups (0: not used in therapeutics but may facilitate the detection of resistance mechanisms; 1: must be studied and always reported; 2: must be studied and selectively reported; 3: must be studied and reported at a second level; and 4: should be studied in urinary tract pathogens isolated in urine and other specimens). Recommended antimicrobial concentrations are adapted from the breakpoints established by EUCAST, CLSI and MENSURA. This approach will lead to more accurate susceptibility testing results with better detection of resistance mechanisms, and allowing to reach the clinical goal of the antibiogram.
AB - The number of clinical microbiology laboratories that have incorporated automatic susceptibility testing devices has increased in recent years. The majority of these systems determine MIC values using microdilution panels or specific cards, with grouping into clinical categories (susceptible, intermediate or resistant) and incorporate expert systems to infer resistance mechanisms. This document presents the recommendations of a group of experts designated by Grupo de Estudio de los Mecanismos de Acción y Resistencia a los Antimicrobianos (GEMARA, Study group on mechanisms of action and resistance to antimicrobial agents) and Mesa Española de Normalización de la Sensibilidad y Resistencia a los Antimicrobianos (MENSURA, Spanish Group for Normalizing Antimicrobial Susceptibility and Antimicrobial Resistance), with the aim of including antimicrobial agents and selecting concentrations for the susceptibility testing panels of automatic systems. The following have been defined: various antimicrobial categories (A: must be included in the study panel; B: inclusion is recommended; and C: inclusion is secondary, but may facilitate interpretative reading of the antibiogram) and groups (0: not used in therapeutics but may facilitate the detection of resistance mechanisms; 1: must be studied and always reported; 2: must be studied and selectively reported; 3: must be studied and reported at a second level; and 4: should be studied in urinary tract pathogens isolated in urine and other specimens). Recommended antimicrobial concentrations are adapted from the breakpoints established by EUCAST, CLSI and MENSURA. This approach will lead to more accurate susceptibility testing results with better detection of resistance mechanisms, and allowing to reach the clinical goal of the antibiogram.
KW - Automatic susceptibility testing systems
KW - Antibiogram
KW - Antimicrobials
KW - Concentrations
UR - http://www.scopus.com/inward/record.url?scp=34547620854&partnerID=8YFLogxK
UR - https://dialnet.unirioja.es/servlet/articulo?codigo=3128465
U2 - 10.1157/13106965
DO - 10.1157/13106965
M3 - Artículo de revisión
AN - SCOPUS:34547620854
SN - 0213-005X
VL - 25
SP - 394
EP - 400
JO - Enfermedades Infecciosas y Microbiologia Clinica
JF - Enfermedades Infecciosas y Microbiologia Clinica
IS - 6
ER -