Recombinant CV-A6 strains related to hand-foot-mouth disease and herpangina at primary care centers (Barcelona, Spain)

Cristina Andrés; Eulàlia Guasch; Maria Piñana; Paula Fernandes; Laura Gimferrer; Diego Van Esso; Maria Gema Codina; Juliana Esperalba; Jorgina Vila; Carlos Rodrigo; Maria Carmen Martín; Francisco Fuentes; Susana Rubio; Tomàs Pumarola; Andrés Antón

doi:10.2217/fmb-2018-0336

Recombinant CV-A6 strains related to hand-foot-mouth disease and herpangina at primary care centers (Barcelona, Spain)

Cristina Andrés, Eulàlia Guasch, Maria Piñana, Paula Fernandes, Laura Gimferrer, Diego Van Esso, Maria Gema Codina, Juliana Esperalba, Jorgina Vila, Carlos Rodrigo, Maria Carmen Martín, Francisco Fuentes, Susana Rubio, Tomàs Pumarola, Andrés Antón

Department of Genetics and Microbiology

Research output: Contribution to journal › Article › Research

4 Citations (Scopus)

Abstract

© 2019 Future Medicine Ltd. Aim: To describe the genetic diversity of enteroviruses (EV) causing hand, foot and mouth disease (HFMD) and herpangina, especially of coxsackievirus (CV)-A6, from patients attended at pediatric primary care centers during the 2017-2018 season. Methods: Phylogenetic analysis of partial VP1 region was performed for genetic characterization. The complete VP1 and 3Dpol proteins were sequenced for lineage determination and detection of recombination events. Results: An 80% of samples were EV laboratory-confirmed. CV-A6 was the most detected (70%) and associated with atypical HFMD (78%). The comparison of VP1 and 3Dpol phylogenies showed evidence of recombination in three strains, in which two shifted to CV-A16 3Dpol. Conclusion: The study provides recent information regarding the nonrecombinant and recombinant EVs related to HFMD at primary care centers.

Original language	English
Pages (from-to)	499-507
Journal	Future Microbiology
Volume	14
DOIs	https://doi.org/10.2217/fmb-2018-0336
Publication status	Published - 1 Apr 2019

Keywords

coxsackievirus A6
enteroviruses
food and mouth disease
hand
herpangina
pediatric infections

Access to Document

10.2217/fmb-2018-0336

Cite this

Andrés, C., Guasch, E., Piñana, M., Fernandes, P., Gimferrer, L., Esso, D. V., Codina, M. G., Esperalba, J., Vila, J., Rodrigo, C., Martín, M. C., Fuentes, F., Rubio, S., Pumarola, T., & Antón, A. (2019). Recombinant CV-A6 strains related to hand-foot-mouth disease and herpangina at primary care centers (Barcelona, Spain). Future Microbiology, 14, 499-507. https://doi.org/10.2217/fmb-2018-0336

@article{aa3cf64171df4646b61748b78f1f6f69,

title = "Recombinant CV-A6 strains related to hand-foot-mouth disease and herpangina at primary care centers (Barcelona, Spain)",

abstract = "{\textcopyright} 2019 Future Medicine Ltd. Aim: To describe the genetic diversity of enteroviruses (EV) causing hand, foot and mouth disease (HFMD) and herpangina, especially of coxsackievirus (CV)-A6, from patients attended at pediatric primary care centers during the 2017-2018 season. Methods: Phylogenetic analysis of partial VP1 region was performed for genetic characterization. The complete VP1 and 3Dpol proteins were sequenced for lineage determination and detection of recombination events. Results: An 80% of samples were EV laboratory-confirmed. CV-A6 was the most detected (70%) and associated with atypical HFMD (78%). The comparison of VP1 and 3Dpol phylogenies showed evidence of recombination in three strains, in which two shifted to CV-A16 3Dpol. Conclusion: The study provides recent information regarding the nonrecombinant and recombinant EVs related to HFMD at primary care centers.",

keywords = "coxsackievirus A6, enteroviruses, food and mouth disease, hand, herpangina, pediatric infections",

author = "Cristina Andr{\'e}s and Eul{\`a}lia Guasch and Maria Pi{\~n}ana and Paula Fernandes and Laura Gimferrer and Esso, {Diego Van} and Codina, {Maria Gema} and Juliana Esperalba and Jorgina Vila and Carlos Rodrigo and Mart{\'i}n, {Maria Carmen} and Francisco Fuentes and Susana Rubio and Tom{\`a}s Pumarola and Andr{\'e}s Ant{\'o}n",

year = "2019",

month = apr,

day = "1",

doi = "10.2217/fmb-2018-0336",

language = "English",

volume = "14",

pages = "499--507",

journal = "Future Microbiology",

issn = "1746-0913",

publisher = "Future Medicine Ltd.",

}

Andrés, C, Guasch, E, Piñana, M, Fernandes, P, Gimferrer, L, Esso, DV, Codina, MG, Esperalba, J, Vila, J, Rodrigo, C, Martín, MC, Fuentes, F, Rubio, S, Pumarola, T & Antón, A 2019, 'Recombinant CV-A6 strains related to hand-foot-mouth disease and herpangina at primary care centers (Barcelona, Spain)', Future Microbiology, vol. 14, pp. 499-507. https://doi.org/10.2217/fmb-2018-0336

TY - JOUR

T1 - Recombinant CV-A6 strains related to hand-foot-mouth disease and herpangina at primary care centers (Barcelona, Spain)

AU - Andrés, Cristina

AU - Guasch, Eulàlia

AU - Piñana, Maria

AU - Fernandes, Paula

AU - Gimferrer, Laura

AU - Esso, Diego Van

AU - Codina, Maria Gema

AU - Esperalba, Juliana

AU - Vila, Jorgina

AU - Rodrigo, Carlos

AU - Martín, Maria Carmen

AU - Fuentes, Francisco

AU - Rubio, Susana

AU - Pumarola, Tomàs

AU - Antón, Andrés

PY - 2019/4/1

Y1 - 2019/4/1

N2 - © 2019 Future Medicine Ltd. Aim: To describe the genetic diversity of enteroviruses (EV) causing hand, foot and mouth disease (HFMD) and herpangina, especially of coxsackievirus (CV)-A6, from patients attended at pediatric primary care centers during the 2017-2018 season. Methods: Phylogenetic analysis of partial VP1 region was performed for genetic characterization. The complete VP1 and 3Dpol proteins were sequenced for lineage determination and detection of recombination events. Results: An 80% of samples were EV laboratory-confirmed. CV-A6 was the most detected (70%) and associated with atypical HFMD (78%). The comparison of VP1 and 3Dpol phylogenies showed evidence of recombination in three strains, in which two shifted to CV-A16 3Dpol. Conclusion: The study provides recent information regarding the nonrecombinant and recombinant EVs related to HFMD at primary care centers.

AB - © 2019 Future Medicine Ltd. Aim: To describe the genetic diversity of enteroviruses (EV) causing hand, foot and mouth disease (HFMD) and herpangina, especially of coxsackievirus (CV)-A6, from patients attended at pediatric primary care centers during the 2017-2018 season. Methods: Phylogenetic analysis of partial VP1 region was performed for genetic characterization. The complete VP1 and 3Dpol proteins were sequenced for lineage determination and detection of recombination events. Results: An 80% of samples were EV laboratory-confirmed. CV-A6 was the most detected (70%) and associated with atypical HFMD (78%). The comparison of VP1 and 3Dpol phylogenies showed evidence of recombination in three strains, in which two shifted to CV-A16 3Dpol. Conclusion: The study provides recent information regarding the nonrecombinant and recombinant EVs related to HFMD at primary care centers.

KW - coxsackievirus A6

KW - enteroviruses

KW - food and mouth disease

KW - hand

KW - herpangina

KW - pediatric infections

U2 - 10.2217/fmb-2018-0336

DO - 10.2217/fmb-2018-0336

M3 - Article

C2 - 31033351

SN - 1746-0913

VL - 14

SP - 499

EP - 507

JO - Future Microbiology

JF - Future Microbiology

ER -

Recombinant CV-A6 strains related to hand-foot-mouth disease and herpangina at primary care centers (Barcelona, Spain)

Abstract

Keywords

Access to Document

Fingerprint

Cite this