Recombinant CV-A6 strains related to hand-foot-mouth disease and herpangina at primary care centers (Barcelona, Spain)

Cristina Andrés, Eulàlia Guasch, Maria Piñana, Paula Fernandes, Laura Gimferrer, Diego Van Esso, Maria Gema Codina, Juliana Esperalba, Jorgina Vila, Carlos Rodrigo, Maria Carmen Martín, Francisco Fuentes, Susana Rubio, Tomàs Pumarola, Andrés Antón

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Abstract

© 2019 Future Medicine Ltd. Aim: To describe the genetic diversity of enteroviruses (EV) causing hand, foot and mouth disease (HFMD) and herpangina, especially of coxsackievirus (CV)-A6, from patients attended at pediatric primary care centers during the 2017-2018 season. Methods: Phylogenetic analysis of partial VP1 region was performed for genetic characterization. The complete VP1 and 3Dpol proteins were sequenced for lineage determination and detection of recombination events. Results: An 80% of samples were EV laboratory-confirmed. CV-A6 was the most detected (70%) and associated with atypical HFMD (78%). The comparison of VP1 and 3Dpol phylogenies showed evidence of recombination in three strains, in which two shifted to CV-A16 3Dpol. Conclusion: The study provides recent information regarding the nonrecombinant and recombinant EVs related to HFMD at primary care centers.
Original languageEnglish
Pages (from-to)499-507
JournalFuture Microbiology
Volume14
DOIs
Publication statusPublished - 1 Apr 2019

Keywords

  • coxsackievirus A6
  • enteroviruses
  • food and mouth disease
  • hand
  • herpangina
  • pediatric infections

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    Andrés, C., Guasch, E., Piñana, M., Fernandes, P., Gimferrer, L., Esso, D. V., Codina, M. G., Esperalba, J., Vila, J., Rodrigo, C., Martín, M. C., Fuentes, F., Rubio, S., Pumarola, T., & Antón, A. (2019). Recombinant CV-A6 strains related to hand-foot-mouth disease and herpangina at primary care centers (Barcelona, Spain). Future Microbiology, 14, 499-507. https://doi.org/10.2217/fmb-2018-0336