TY - JOUR
T1 - Reciprocal chromosome painting shows that squirrels, unlike murid rodents, have a highly conserved genome organization
AU - Stanyon, Roscoe
AU - Stone, Gary
AU - Garcia, Montserrat
AU - Froenicke, Lutz
PY - 2003/8/1
Y1 - 2003/8/1
N2 - We present the first report of reciprocal chromosome painting between humans and a rodent. Gene mapping and sequencing data lead to the generalization that rodent genomes are highly rearranged. In contrast, our results show a surprising conservation of genome structure between humans and squirrels. The synteny of 12 human chromosomes was entirely conserved (5, 6, 9, 11, 13-15, 17, 18, 20, 21, and X). Of the 12 syntenic associations of human chromosomes present in the squirrel, six are well-known ancestral eutherian associations (3/21, 4/8, 7/16, 12/22, 14/15, 16/19). Apparently, few derived translocations characterize the evolutionary origin of the rodents. One association (10p/1qter) may be a cladistic marker for the cohort Glires, linking rodents and lagomorphs. © 2003 Elsevier Science (USA). All rights reserved.
AB - We present the first report of reciprocal chromosome painting between humans and a rodent. Gene mapping and sequencing data lead to the generalization that rodent genomes are highly rearranged. In contrast, our results show a surprising conservation of genome structure between humans and squirrels. The synteny of 12 human chromosomes was entirely conserved (5, 6, 9, 11, 13-15, 17, 18, 20, 21, and X). Of the 12 syntenic associations of human chromosomes present in the squirrel, six are well-known ancestral eutherian associations (3/21, 4/8, 7/16, 12/22, 14/15, 16/19). Apparently, few derived translocations characterize the evolutionary origin of the rodents. One association (10p/1qter) may be a cladistic marker for the cohort Glires, linking rodents and lagomorphs. © 2003 Elsevier Science (USA). All rights reserved.
KW - Chromosomal homology
KW - Phylogeny
KW - Sciurids
KW - Synteny
KW - Zoo-FISH
U2 - https://doi.org/10.1016/S0888-7543(03)00109-5
DO - https://doi.org/10.1016/S0888-7543(03)00109-5
M3 - Article
VL - 82
SP - 245
EP - 249
JO - Genomics
JF - Genomics
SN - 0888-7543
ER -