Recent population decline and selection shape diversity of taxol-related genes

C. Burgarella, M. NavascuÉs, M. Zabal-Aguirre, E. Berganzo, M. Riba, M. Mayol, G. G. Vendramin, S. C. González-MartÍnez

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)


Taxanes are defensive metabolites produced by Taxus species (yews) and used in anticancer therapies. Despite their medical interest, patterns of natural diversity in taxane-related genes are unknown. We examined variation at five main genes of Taxus baccata in the Iberian Peninsula, a region where unique yew genetic resources are endangered. We looked at several gene features and applied complementary neutrality tests, including diversity/divergence tests, tests solely based on site frequency spectrum (SFS) and Zeng's compound tests. To account for specific demography, microsatellite data were used to infer historical changes in population size based on an Approximate Bayesian Computation (ABC) approach. Polymorphism-divergence tests pointed to positive selection for genes TBT and TAT and balancing selection for DBAT. In addition, neutrality tests based on SFS found that while a recent reduction in population size may explain most statistics' values, selection may still be in action in genes TBT and DBAT, at least in some populations. Molecular signatures on taxol genes suggest the action of frequent selective waves with different direction or intensity, possibly related to varying adaptive pressures produced by the host-enemy co-evolution on defence-related genes. Such natural selection processes may have produced taxane variants still undiscovered. © 2012 Blackwell Publishing Ltd.
Original languageEnglish
Pages (from-to)3006-3021
JournalMolecular Ecology
Publication statusPublished - 1 Jun 2012


  • ABC inference
  • Taxus baccata (European yew)
  • bottleneck
  • natural selection
  • neutrality tests
  • taxol genes


Dive into the research topics of 'Recent population decline and selection shape diversity of taxol-related genes'. Together they form a unique fingerprint.

Cite this