Recent advances in small molecule NMR: Improved HSQC and HSQMBC experiments

Laura Castañar; Teodor Parella

doi:10.1016/bs.arnmr.2014.10.004

Recent advances in small molecule NMR: Improved HSQC and HSQMBC experiments

Laura Castañar, Teodor Parella

Research output: Chapter in Book › Chapter › Research › peer-review

28 Citations (Scopus)

Abstract

© 2015 Elsevier Ltd. A general description of the latest developments in heteronuclear single-quantum correlation and heteronuclear single-quantum multiple bond correlation experiments designed for small molecules at the natural isotopic abundance is reported. A discussion is made on the details introduced into novel NMR pulse sequences with special emphasis on modern concepts such as fast NMR or pure shift NMR and also on robust techniques affording pure in-phase multiplet patterns, which are amenable for a simpler and a more accurate analysis. The suitability of some of these methods for the quantitative measurement of one-bond and long-range proton-carbon coupling values in molecules in isotropic and weakly aligned anisotropic conditions is also reviewed.

Original language	English
Title of host publication	Annual Reports on NMR Spectroscopy
Pages	163-232
Number of pages	69
Volume	84
DOIs	https://doi.org/10.1016/bs.arnmr.2014.10.004
Publication status	Published - 1 Jan 2015

Keywords

HSQC
HSQMBC
NMR
Proton-carbon coupling constants
Pulse sequence development
Pure Shift NMR

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10.1016/bs.arnmr.2014.10.004

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abstract = "{\textcopyright} 2015 Elsevier Ltd. A general description of the latest developments in heteronuclear single-quantum correlation and heteronuclear single-quantum multiple bond correlation experiments designed for small molecules at the natural isotopic abundance is reported. A discussion is made on the details introduced into novel NMR pulse sequences with special emphasis on modern concepts such as fast NMR or pure shift NMR and also on robust techniques affording pure in-phase multiplet patterns, which are amenable for a simpler and a more accurate analysis. The suitability of some of these methods for the quantitative measurement of one-bond and long-range proton-carbon coupling values in molecules in isotropic and weakly aligned anisotropic conditions is also reviewed.",

keywords = "HSQC, HSQMBC, NMR, Proton-carbon coupling constants, Pulse sequence development, Pure Shift NMR",

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doi = "10.1016/bs.arnmr.2014.10.004",

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AU - Parella, Teodor

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N2 - © 2015 Elsevier Ltd. A general description of the latest developments in heteronuclear single-quantum correlation and heteronuclear single-quantum multiple bond correlation experiments designed for small molecules at the natural isotopic abundance is reported. A discussion is made on the details introduced into novel NMR pulse sequences with special emphasis on modern concepts such as fast NMR or pure shift NMR and also on robust techniques affording pure in-phase multiplet patterns, which are amenable for a simpler and a more accurate analysis. The suitability of some of these methods for the quantitative measurement of one-bond and long-range proton-carbon coupling values in molecules in isotropic and weakly aligned anisotropic conditions is also reviewed.

AB - © 2015 Elsevier Ltd. A general description of the latest developments in heteronuclear single-quantum correlation and heteronuclear single-quantum multiple bond correlation experiments designed for small molecules at the natural isotopic abundance is reported. A discussion is made on the details introduced into novel NMR pulse sequences with special emphasis on modern concepts such as fast NMR or pure shift NMR and also on robust techniques affording pure in-phase multiplet patterns, which are amenable for a simpler and a more accurate analysis. The suitability of some of these methods for the quantitative measurement of one-bond and long-range proton-carbon coupling values in molecules in isotropic and weakly aligned anisotropic conditions is also reviewed.

KW - HSQC

KW - HSQMBC

KW - NMR

KW - Proton-carbon coupling constants

KW - Pulse sequence development

KW - Pure Shift NMR

U2 - 10.1016/bs.arnmr.2014.10.004

DO - 10.1016/bs.arnmr.2014.10.004

M3 - Chapter

SN - 0066-4103

VL - 84

SP - 163

EP - 232

BT - Annual Reports on NMR Spectroscopy

ER -

Recent advances in small molecule NMR: Improved HSQC and HSQMBC experiments

Abstract

Keywords

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