Real life outcomes of patients aged ≥75 years old with acute promyelocytic leukemia: experience of the PETHEMA registry

Olga Salamero, David Martínez-Cuadrón, Marta Sobas, Celina Benavente, Susana Vives, Javier De la Serna, Manuel Pérez-Encinas, Lourdes Escoda, Cristina Gil, Salut Brunet, Fernando Ramos, Jordi Esteve, Mariluz Amigo, Isabel Krsnik, Félix Manso, Jesús Arias, José González-Campos, Josefina Serrano, Jalanta Oleksiuk, Manuel BarriosRaimundo García-Boyero, Andrés Novo, Miguel A. Sanz, Pau Montesinos

Research output: Contribution to journalArticleResearch

1 Citation (Scopus)

Abstract

© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Acute promyelocytic leukemia is infrequent among patients aged ≥75 years old, a population that is rarely eligible for clinical protocols. This study aims to analyze the treatment strategies and clinical outcomes of very old APL patients reported to the international PETHEMA registry. Between 1997 and 2017, among 2501 APL cases registered 120 were ≥75 years old. Treatment approaches were: AIDA regimen, 79 patients; ATRA alone, 23; 16, supportive care (SC) and 2, other strategies. Patients treated with AIDA were younger, had better ECOG and lower leukocytes. Complete remission (CR) was achieved in 65% of AIDA-group vs. 45% in the ATRA-group, being infections followed by bleeding the most frequent causes of induction death. Patients in CR after AIDA showed 3-year DFS of 73%. Our real-life series of very old APL patients provides a reference basis for future treatment strategies aiming to improve clinical outcomes in this challenging population.
Original languageEnglish
JournalLeukemia and Lymphoma
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • APL prognostic factors
  • APL real life outcomes
  • Elderly APL
  • induction mortality in APL

Fingerprint Dive into the research topics of 'Real life outcomes of patients aged ≥75 years old with acute promyelocytic leukemia: experience of the PETHEMA registry'. Together they form a unique fingerprint.

Cite this