Reaction between proline and γ-oxo α,β-unsaturated esters: New access to polysubstituted pyrrolizidines

Pedro De March, Laia Elias, Marta Figueredo, Josep Font

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

The reactions between proline and several γ-oxo α,β-unsaturated esters have been studied in detail. The products isolated are in all cases derived from one molecule of proline and two molecules of the ester. The new polysubstituted pyrrolizidines result from the cycloaddition of an azomethine ylide to a second molecule of the unsaturated ester in a stereoselective manner. © 2002 Elsevier Science Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)2667-2672
JournalTetrahedron
Volume58
Issue number13
DOIs
Publication statusPublished - 25 Mar 2002

Keywords

  • Azomethine ylides
  • Pyrrolizidines
  • Regiochemistry
  • Stereochemistry

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