Raynaud's phenomenon

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Raynauds phenomenon is a frequent reason forseeking of medicalattention, since it affects 35% of the population. It is characterized by sudden, transient and recurrent episodes of pallor and/or digital cyanosis, after exposure to cold or stressful situations. No known underlying illness is identified in over 80% of cases and consequently these cases are classified as primary Raynauds phenomenon. Connective tissue diseases, particularly systemic sclerosis, are the main causes of thephenomenon. Once a complete clinical and physical evaluation rule out other causes, a nailfold capillaroscopy and antinuclear antibodies determination are the most useful adjunctive tests. Mild Raynauds phenomenon can be managed almost exclusively with conservative non-pharmacological lifestyle modifications. However, if a patient develops a severe vascular condition a suitable vasodilator treatment is needed. When critical digital ischemia develops, intravenous treatment with prostaglandin analogues and surgery may be usefu. © 2008 Elsevier Españ a, S.L. All rights reserved.
Original languageEnglish
Pages (from-to)712-718
JournalMedicina Clinica
Issue number18
Publication statusPublished - 16 May 2009


  • Antinuclear antibodies
  • Capillaroscopy
  • Diagnosis
  • Raynaud's phenomenon
  • Treatment


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