Rapid headspace gas chromatographic method for the determination of liquid/gas partition coefficients

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    Abstract

    A rapid, efficient and low-cost headspace technique useful for the determination of liquid/gas partition coefficients of gases and volatile substances of low and intermediate solubility is described. The equilibration step is carried out at constant pressure using glass syringes, with a ratio of liquid/gas phase volumes of ca. 1:3; after 30 min at the desired temperature, the headspace is recovered by transfer into another syringe and analyzed by gas chromatography. A study of the partition coefficients in water at 37°C of 27 volatile compounds demonstrated that the method is fully applicable for all gases, with exception of those with a partition coefficient higher than 300. © 1989.
    Original languageEnglish
    Pages (from-to)271-280
    JournalJournal of Chromatography B: Biomedical Sciences and Applications
    Volume491
    DOIs
    Publication statusPublished - 1 Jan 1989

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