Radiographic-anatomy, natural history and extension pathways of parotid and submandibular gland cancers

Julian Biau*, Chris Nutting, Johannes A. Langendijk, Thomas Frédéric-Moreau, Juliette Thariat, Lucie Piram, Romain Bellini, Nicolas Saroul, Nathalie Pham Dang, Brian O'Sullivan, Jordi Giralt, Pierre Blanchard, Jean Bourhis, Michel Lapeyre

*Corresponding author for this work

Research output: Contribution to journalReview articleResearchpeer-review


Intensity-modulated radiotherapy has been widely used routinely in recent past years for post-operative radiotherapy of salivary gland cancers Because of the sharp dose fall off outside of target volumes with IMRT, each volume must be strictly and rigorously defined, as the areas not specifically included in the target volume will not be treated to a therapeutic dose. The selection and delineation of these volumes is complex and requires extensive knowledge of parotid and submandibular gland cancer radiographic-anatomy, natural history and extension pathways (including local tumor spread, PNI risks and regional spread), which are detailed in the present article.

Original languageEnglish
Pages (from-to)48-54
Number of pages7
JournalRadiotherapy and Oncology
Publication statusPublished - May 2022


  • Extension pathways
  • Parotid gland
  • Radiotherapy
  • Salivary gland cancers
  • Submandibular gland


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