R2d2 Drives Selfish Sweeps in the House Mouse

John P. Didion, Andrew P. Morgan, Liran Yadgary, Timothy A. Bell, Rachel C. McMullan, Lydia Ortiz De Solorzano, Janice Britton-Davidian, Carol J. Bult, Karl J. Campbell, Riccardo Castiglia, Yung Hao Ching, Amanda J. Chunco, James J. Crowley, Elissa J. Chesler, Daniel W. Förster, John E. French, Sofia I. Gabriel, Daniel M. Gatti, Theodore Garland, Eva B. Giagia-AthanasopoulouMabel D. Giménez, Sofia A. Grize, Islam Gündüz, Andrew Holmes, Heidi C. Hauffe, Jeremy S. Herman, James M. Holt, Kunjie Hua, Wesley J. Jolley, Anna K. Lindholm, María J. López-Fuster, George Mitsainas, Maria Da Luz Mathias, Leonard McMillan, Maria Da Graça Morgado Ramalhinho, Barbara Rehermann, Stephan P. Rosshart, Jeremy B. Searle, Meng Shin Shiao, Emanuela Solano, Karen L. Svenson, Patricia Thomas-Laemont, David W. Threadgill, Jacint Ventura, George M. Weinstock, Daniel Pomp, Gary A. Churchill, Fernando Pardo Manuel De Villena

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Abstract

© 2016 The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. A selective sweep is the result of strong positive selection driving newly occurring or standing genetic variants to fixation, and can dramatically alter the pattern and distribution of allelic diversity in a population. Population-level sequencing data have enabled discoveries of selective sweeps associated with genes involved in recent adaptations in many species. In contrast, much debate but little evidence addresses whether "selfish" genes are capable of fixation - thereby leaving signatures identical to classical selective sweeps - despite being neutral or deleterious to organismal fitness. We previously described R2d2, a large copy-number variant that causes nonrandom segregation of mouse Chromosome 2 in females due to meiotic drive. Here we show population-genetic data consistent with a selfish sweep driven by alleles of R2d2 with high copy number (R2d2HC) in natural populations. We replicate this finding in multiple closed breeding populations from six outbred backgrounds segregating for R2d2 alleles. We find that R2d2HC rapidly increases in frequency, and in most cases becomes fixed in significantly fewer generations than can be explained by genetic drift. R2d2HC is also associated with significantly reduced litter sizes in heterozygous mothers, making it a true selfish allele. Our data provide direct evidence of populations actively undergoing selfish sweeps, and demonstrate that meiotic drive can rapidly alter the genomic landscape in favor of mutations with neutral or even negative effects on overall Darwinian fitness. Further study will reveal the incidence of selfish sweeps, and will elucidate the relative contributions of selfish genes, adaptation and genetic drift to evolution.
Original languageEnglish
Pages (from-to)1381-1395
JournalMolecular Biology and Evolution
Volume33
Issue number6
DOIs
Publication statusPublished - 2 Jun 2016

Keywords

  • House Mouse
  • Meiotic Drive
  • R2d2
  • Selective Sweep
  • Selfish Genes

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