Quatsomes: Vesicles formed by self-assembly of sterols and quaternary ammonium surfactants

Lidia Ferrer-Tasies, Evelyn Moreno-Calvo, Mary Cano-Sarabia, Marcel Aguilella-Arzo, Angelina Angelova, Sylviane Lesieur, Susagna Ricart, Jordi Faraudo, Nora Ventosa, Jaume Veciana

    Research output: Contribution to journalArticleResearchpeer-review

    70 Citations (Scopus)


    Thermodynamically stable nanovesicle structures are of high interest for academia and industry in a wide variety of application fields, ranging from preparation of nanomaterials to nanomedicine. Here, we show the ability of quaternary ammonium surfactants and sterols to self-assemble, forming stable amphiphilic bimolecular building-blocks with the appropriate structural characteristics to form in aqueous phases, closed bilayers, named quatsomes, with outstanding stability, with time and temperature. The molecular self-assembling of cholesterol and surfactant cetyltrimethylammonium bromide (CTAB) was studied by quasi-elastic light scattering, cryogenic transmission electron microscopy, turbidity (optical density) measurements, and molecular dynamic simulations with atomistic detail, upon varying the cholesterol-to- surfactant molar ratio. As pure species, CTAB forms micelles and insoluble cholesterol forms crystals in water. However, our molecular dynamic simulations reveal that the synergy between CTAB and cholesterol molecules makes them self-assemble into bimolecular amphiphiles and then into bilayers in the presence of water. These bilayers have the same structure of those formed by double-tailed unimolecular amphiphiles. © 2013 American Chemical Society.
    Original languageEnglish
    Pages (from-to)6519-6528
    Issue number22
    Publication statusPublished - 4 Jun 2013


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