Quantifying the allosteric interactions within a G-protein-coupled receptor heterodimer

Bin Zhou, Jesús Giraldo*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)


G-protein-coupled receptors are central to signal transduction and cell communication. The possibility that cells use receptor heteromerization to modulate individual receptor pathways is a surmise that cannot be precluded. Given the complexity of these processes, mathematical models contribute to understanding how receptors and their respective ligands regulate signaling. Here, a mathematical model is presented that quantifies the allosteric interactions within a receptor heterodimer. The model is based on the operational model of allosterism including constitutive receptor activity, which provides the pharmacological analysis of heteromerization with well-established and widely used modeling and fitting procedures.

Original languageEnglish
Pages (from-to)7-11
Number of pages5
JournalDrug Discovery Today
Issue number1
Publication statusPublished - Jan 2018


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