Quality of life in Cushing’s syndrome

Alicia Santos, Iris Crespo, Anna Aulinas, Eugenia Resmini, Elena Valassi, Susan M. Webb

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)


© 2015, Springer Science+Business Media New York. Introduction: Cushing syndrome (CS) of any etiology (adrenal, pituitary or ectopic) impacts negatively on health-related quality of life (QoL), especially in active hypercortisolism but also after endocrine cure. Both generic questionnaires like the short-form 36 health survey -SF-36- and the derived SF-12, or the Hospital Anxiety and Depression Scale (HADS), and disease-specific measures like the CushingQoL and the Tuebingen CD-25 questionnaires have provided information on the impact of CS on patients perceived health.Materials and methods: Studies published since January 2013 until November 2014 on QoL in patients with CS were identified, reviewed and summarized.Conclusions: Treatment of CS improves patients perceived QoL, but it often takes many months and often never normalizes. In parallel to persistent QoL impairment in cured CS, brain and cerebellar volume are reduced. Depression, anxiety and cognitive dysfunction are common. Pediatric patients with CS also present worse QoL than normal children, as well as additional issues like delayed growth and pubertal development, next to abnormal body composition, psychological and cognitive maturation. Fluoxetine has been suggested as a neuroprotectant and antidepressant for patients with CS, although no prospective studies are yet available. The CushingQoL questionnaire has been mapped to well-validated instruments like SF-36 or EQ-5D, and therefore may be used in cost-utility and other health economy studies.
Original languageEnglish
Pages (from-to)195-200
Issue number2
Publication statusPublished - 1 Apr 2015


  • Cushing syndrome
  • Quality of life
  • Therapy for Cushing syndrome


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