This article goes in depth in the relationship between employability skills and quality of life of people with mild and moderate intellectual disability who work in a special employment center (CEE), as a determining factor in their level of socio-community inclusion. Data was collected by means of a questionnaire on labor competences (own elaboration), as well as through the scale of quality of life by Schalock and Verdugo (2008) with 100 workers of 15 CEE. The worker’s supervisor answered both. People in the sample have a low level of quality of life, but high in job skills. There is no relationship between both variables. In terms of quality of life, young people show better levels of personal development than those over 45 years of age; and men present better results in interpersonal relationships. High levels of competence do not differ according to age or gender. Results show the need for a longitudinal educational action centered on the person, already initiated in schooling, to promote the domains of the quality of life and to continue throughout life. On the other hand, job training developed in the CEE shows good results in the professional skills of participants in the study. The specific groups that require priority actions are those over 45 years old, to promote quality active aging, as well as women, to avoid double discrimination to which they are subjected (disability and gender).