TY - JOUR
T1 - Pulmonary Arterial Hypertension and Neonatal Arterial Switch Surgery for Correction of Transposition of the Great Arteries
AU - Domínguez Manzano, Paula
AU - Mendoza Soto, Alberto
AU - Román Barba, Violeta
AU - Moreno Galdó, Antonio
AU - Galindo Izquierdo, Alberto
PY - 2016/9/1
Y1 - 2016/9/1
N2 - © 2016 Sociedad Española de Cardiología Introduction and objectives There are few reports of the appearance of pulmonary arterial hypertension following arterial switch surgery in the neonatal period to correct transposition of the great arteries. We assessed the frequency and clinical pattern of this complication in our series of patients. Methods Our database was reviewed to select patients with transposition of the great arteries corrected by neonatal arterial switch at our hospital and who developed pulmonary hypertension over time. Results We identified 2 (1.3%) patients with transposition of the great arteries successfully repaired in the first week of life who later experienced pulmonary arterial hypertension. The first patient was a 7-year-old girl diagnosed with severe pulmonary hypertension at age 8 months who did not respond to medical treatment and required lung transplantation. The anatomic pathology findings were consistent with severe pulmonary arterial hypertension. The second patient was a 24-month-old boy diagnosed with severe pulmonary hypertension at age 13 months who did not respond to medical therapy. Conclusions Pulmonary hypertension is a rare but very severe complication that should be investigated in all patients with transposition of the great arteries who have undergone neonatal arterial switch, in order to start early aggressive therapy for affected patients, given the poor therapeutic response and poor prognosis involved. Full English text available from: www.revespcardiol.org/en
AB - © 2016 Sociedad Española de Cardiología Introduction and objectives There are few reports of the appearance of pulmonary arterial hypertension following arterial switch surgery in the neonatal period to correct transposition of the great arteries. We assessed the frequency and clinical pattern of this complication in our series of patients. Methods Our database was reviewed to select patients with transposition of the great arteries corrected by neonatal arterial switch at our hospital and who developed pulmonary hypertension over time. Results We identified 2 (1.3%) patients with transposition of the great arteries successfully repaired in the first week of life who later experienced pulmonary arterial hypertension. The first patient was a 7-year-old girl diagnosed with severe pulmonary hypertension at age 8 months who did not respond to medical treatment and required lung transplantation. The anatomic pathology findings were consistent with severe pulmonary arterial hypertension. The second patient was a 24-month-old boy diagnosed with severe pulmonary hypertension at age 13 months who did not respond to medical therapy. Conclusions Pulmonary hypertension is a rare but very severe complication that should be investigated in all patients with transposition of the great arteries who have undergone neonatal arterial switch, in order to start early aggressive therapy for affected patients, given the poor therapeutic response and poor prognosis involved. Full English text available from: www.revespcardiol.org/en
KW - Arterial switch
KW - Pulmonary arterial hypertension
KW - Transposition of the great arteries
U2 - 10.1016/j.recesp.2016.01.035
DO - 10.1016/j.recesp.2016.01.035
M3 - Article
SN - 0300-8932
VL - 69
SP - 836
EP - 841
JO - Revista Espanola de Cardiologia
JF - Revista Espanola de Cardiologia
IS - 9
ER -