Psoriasis and systemic inflammatory diseases: Potential mechanistic links between skin disease and co-morbid conditions

Batya B. Davidovici, Naveed Sattar, Prinz C. Jörg, Luis Puig, Paul Emery, Jonathan N. Barker, Peter Van De Kerkhof, Mona Ståhle, Frank O. Nestle, Giampiero Girolomoni, James G. Krueger

Research output: Contribution to journalReview articleResearchpeer-review

458 Citations (Scopus)

Abstract

Psoriasis is now classified as an immune-mediated inflammatory disease (IMID) of the skin. It is being recognized that patients with various IMIDs, including psoriasis, are at higher risk of developing systemic co-morbidities, e.g., cardiovascular disease (CVD), metabolic syndrome, and overt diabetes. In non-psoriatic individuals, the pathophysiology of obesity, aberrant adipocyte metabolism, diabetes, and CVDs involves immune-mediated or inflammatory pathways. IMIDs may impact these co-morbid conditions through shared genetic risks, common environmental factors, or common inflammatory pathways that are co-expressed in IMIDs and target organs. Given that pathogenic immune pathways in psoriasis are now well worked out and a large number of inflammatory mediators have been identified in skin lesions, in this review we will consider possible mechanistic links between skin inflammation and increased risks of (1) obesity or metabolic alterations and (2) CVD. In particular, we will discuss how well-established risk factors for CVD can originate from inflammation in other tissues. © 2010 The Society for Investigative Dermatology.
Original languageEnglish
Pages (from-to)1785-1796
JournalJournal of Investigative Dermatology
Volume130
Issue number7
DOIs
Publication statusPublished - 1 Jul 2010

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