Under the usual conditions, the Pd-catalyzed arylation does not involve an electrophilic aromatic substitution reaction. On the basis of DFT calculations, we propose a mechanism for the Pd-catalyzed arylation that involves a proton abstraction by a carbonate or related ligand and that provides a satisfactory explanation for the experimental data. Copyright © 2006 American Chemical Society.
García-Cuadrado, D., Braga, A. A. C., Maseras, F., & Echavarren, A. M. (2006). Proton abstraction mechanism for the palladium-catalyzed intramolecular arylation. Journal of the American Chemical Society, 128(4), 1066-1067. https://doi.org/10.1021/ja056165v