Protein polymorphism is negatively correlated with conservation of intronic sequences and complexity of expression patterns in Drosophila melanogaster

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

We report a significant negative correlation between nonsynonymous polymorphism and intron length in Drosophila melanogaster. This correlation is similar to that between protein divergence and intron length previously reported in Drosophila. We show that the relationship can be explained by the content of conserved noncoding sequences (CNS) within introns. In addition, genes with a high regulatory complexity and many genetic interactions also exhibit larger amounts of CNS within their introns and lower values of nonsynonymous polymorphism. The present study provides relevant evidence on the importance of intron content and expression patterns on the levels of coding polymorphism. © 2007 Springer Science+Business Media, LLC.
Original languageEnglish
Pages (from-to)511-518
JournalJournal of Molecular Evolution
Volume64
DOIs
Publication statusPublished - 1 May 2007

Keywords

  • Coding nucleotide polymorphism
  • Conserved noncoding sequences
  • Drosophila melanogaster
  • Gene expression pattern
  • Protein evolution

Fingerprint Dive into the research topics of 'Protein polymorphism is negatively correlated with conservation of intronic sequences and complexity of expression patterns in Drosophila melanogaster'. Together they form a unique fingerprint.

  • Cite this