Protein oxidative folding in the intermembrane mitochondrial space: More than protein trafficking

Hugo Fraga, Salvador Ventura

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

The process of oxidative folding in the intermembrane mitochondrial space (IMS) is an exciting field of research because folding is simultaneously coupled to protein translocation and functional regulation. Contrary to the endoplasmatic reticulum ER where several chaperones of the disulfide isomerase family exist, oxidative folding in the IMS is exclusively catalyzed by the oxoreductase Mia40 that recognizes a group of proteins with characteristic cysteine motifs organized in twin CX 3C, twin CX 9C or CX 2C motifs. In this review, we discuss the structural and biochemical studies leading to our current understanding of the Mia40 pathway as well as the open questions on the field. In fact, despite significant advances, several key points on the Mia40 pathway remain to clarify namely on the molecular mechanism trough which substrate oxidative folding is catalyzed. This issue is receiving increasing attention since failures in the import, sorting and folding of mitochondrial proteins is related to an increasing number of debilitating human disorders. © 2012 Bentham Science Publishers.
Original languageEnglish
Pages (from-to)224-231
JournalCurrent Protein and Peptide Science
Volume13
DOIs
Publication statusPublished - 1 May 2012

Keywords

  • Cysteine motifs
  • Disulfide bonds
  • Erv1
  • Intermembrane space
  • Mia40
  • Mitochondria
  • Oxidative protein folding
  • Protein import

Fingerprint Dive into the research topics of 'Protein oxidative folding in the intermembrane mitochondrial space: More than protein trafficking'. Together they form a unique fingerprint.

Cite this