TY - JOUR
T1 - Prospective registry of symptomatic severe aortic stenosis in octogenarians: A need for intervention
AU - Martínez-Sellés, M.
AU - Gómez Doblas, J. J.
AU - Carro Hevia, A.
AU - García de la Villa, B.
AU - Ferreira-González, I.
AU - Alonso Tello, A.
AU - Andión Ogando, R.
AU - Ripoll Vera, T.
AU - Arribas Jiménez, A.
AU - Carrillo, P.
AU - Rodríguez Pascual, C.
AU - Casares i Romeva, M.
AU - Borras, X.
AU - Cornide, L.
AU - López-Palop, R.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Objective: To study the factors associated with choice of therapy and prognosis in octogenarians with severe symptomatic aortic stenosis (AS). Study Design: Prospective, observational, multicenter registry. Centralized follow-up included survival status and, if possible, mode of death and Katz index. Setting: Transnational registry in Spain. Subjects: We included 928 patients aged ≥80 years with severe symptomatic AS. Interventions: Aortic-valve replacement (AVR), transcatheter aortic-valve implantation (TAVI) or conservative therapy. Main outcome measures: All-cause death. Results: Mean age was 84.2 ± 3.5 years, and only 49.0% were independent (Katz index A). The most frequent planned management was conservative therapy in 423 (46%) patients, followed by TAVI in 261 (28%) and AVR in 244 (26%). The main reason against recommending AVR in 684 patients was high surgical risk [322 (47.1%)], other medical motives [193 (28.2%)], patient refusal [134 (19.6%)] and family refusal in the case of incompetent patients [35 (5.1%)]. The mean time from treatment decision to AVR was 4.8 ± 4.6 months and to TAVI 2.1 ± 3.2 months, P < 0.001. During follow-up (11.2-38.9 months), 357 patients (38.5%) died. Survival rates at 6, 12, 18 and 24 months were 81.8%, 72.6%, 64.1% and 57.3%, respectively. Planned intervention, adjusted for multiple propensity score, was associated with lower mortality when compared with planned conservative treatment: TAVI Hazard ratio (HR) 0.68 (95% confidence interval [CI] 0.49-0.93; P = 0.016) and AVR HR 0.56 (95% CI 0.39-0.8; P = 0.002). Conclusion: Octogenarians with symptomatic severe AS are frequently managed conservatively. Planned conservative management is associated with a poor prognosis. © 2013 The Association for the Publication of the Journal of Internal Medicine.
AB - Objective: To study the factors associated with choice of therapy and prognosis in octogenarians with severe symptomatic aortic stenosis (AS). Study Design: Prospective, observational, multicenter registry. Centralized follow-up included survival status and, if possible, mode of death and Katz index. Setting: Transnational registry in Spain. Subjects: We included 928 patients aged ≥80 years with severe symptomatic AS. Interventions: Aortic-valve replacement (AVR), transcatheter aortic-valve implantation (TAVI) or conservative therapy. Main outcome measures: All-cause death. Results: Mean age was 84.2 ± 3.5 years, and only 49.0% were independent (Katz index A). The most frequent planned management was conservative therapy in 423 (46%) patients, followed by TAVI in 261 (28%) and AVR in 244 (26%). The main reason against recommending AVR in 684 patients was high surgical risk [322 (47.1%)], other medical motives [193 (28.2%)], patient refusal [134 (19.6%)] and family refusal in the case of incompetent patients [35 (5.1%)]. The mean time from treatment decision to AVR was 4.8 ± 4.6 months and to TAVI 2.1 ± 3.2 months, P < 0.001. During follow-up (11.2-38.9 months), 357 patients (38.5%) died. Survival rates at 6, 12, 18 and 24 months were 81.8%, 72.6%, 64.1% and 57.3%, respectively. Planned intervention, adjusted for multiple propensity score, was associated with lower mortality when compared with planned conservative treatment: TAVI Hazard ratio (HR) 0.68 (95% confidence interval [CI] 0.49-0.93; P = 0.016) and AVR HR 0.56 (95% CI 0.39-0.8; P = 0.002). Conclusion: Octogenarians with symptomatic severe AS are frequently managed conservatively. Planned conservative management is associated with a poor prognosis. © 2013 The Association for the Publication of the Journal of Internal Medicine.
KW - Ageing
KW - Aortic stenosis
KW - Aortic surgery
U2 - 10.1111/joim.12174
DO - 10.1111/joim.12174
M3 - Article
VL - 275
SP - 608
EP - 620
JO - Journal of Internal Medicine
JF - Journal of Internal Medicine
SN - 0954-6820
IS - 6
ER -