Prospective evaluation of latent tuberculosis with interferon-γ release assays in drug and alcohol abusers

I. Rivas; I. Latorre; A. Sanvisens; J. Domínguez; J. Tor; C. Prat; C. Rey-Joly; R. Muga

doi:10.1017/S0950268809002131

Prospective evaluation of latent tuberculosis with interferon-γ release assays in drug and alcohol abusers

I. Rivas, I. Latorre, A. Sanvisens, J. Domínguez, J. Tor, C. Prat, C. Rey-Joly, R. Muga

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

12 Citations (Scopus)

Abstract

In vitro tests have been developed for the diagnosis of tuberculosis (TB) infection. The objective was to analyse latent TB infection in drug and alcohol abusers through two interferon-γ techniques. One hundred and thirty-nine patients were admitted between February 2006 and May 2007. Mean age was 39.8 years [31% HIV positive]. The enzyme immunoassay (EIA) and enzyme-linked immunospot (ELISPOT) interferon- γ assays were positive in 34% of patients with an agreement of 83% (κ = 0.63). Tuberculin skin test (TST) was positive in 29% of patients and the agreement of TST with EIA and ELISPOT interferon- γ assays was 85% (κ = 0.62) and 83% (κ=0.57), respectively. Almost 50% of patients with history of TB had a positive in vitro test. In conclusion, we observed a high prevalence of latent TB and good agreement between the new in vitro tests that otherwise may continue to be positive long after developing TB disease. © 2009 Cambridge University Press.

Original language	English
Pages (from-to)	1342-1347
Journal	Epidemiology and Infection
Volume	137
Issue number	9
DOIs	https://doi.org/10.1017/S0950268809002131
Publication status	Published - 14 Sep 2009

Keywords

Diagnosis of infection
Drug abuse
Interferon-γ
Tuberculosis

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title = "Prospective evaluation of latent tuberculosis with interferon-γ release assays in drug and alcohol abusers",

abstract = "In vitro tests have been developed for the diagnosis of tuberculosis (TB) infection. The objective was to analyse latent TB infection in drug and alcohol abusers through two interferon-γ techniques. One hundred and thirty-nine patients were admitted between February 2006 and May 2007. Mean age was 39.8 years [31% HIV positive]. The enzyme immunoassay (EIA) and enzyme-linked immunospot (ELISPOT) interferon- γ assays were positive in 34% of patients with an agreement of 83% (κ = 0.63). Tuberculin skin test (TST) was positive in 29% of patients and the agreement of TST with EIA and ELISPOT interferon- γ assays was 85% (κ = 0.62) and 83% (κ=0.57), respectively. Almost 50% of patients with history of TB had a positive in vitro test. In conclusion, we observed a high prevalence of latent TB and good agreement between the new in vitro tests that otherwise may continue to be positive long after developing TB disease. {\textcopyright} 2009 Cambridge University Press.",

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author = "I. Rivas and I. Latorre and A. Sanvisens and J. Dom{\'i}nguez and J. Tor and C. Prat and C. Rey-Joly and R. Muga",

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T1 - Prospective evaluation of latent tuberculosis with interferon-γ release assays in drug and alcohol abusers

AU - Rivas, I.

AU - Latorre, I.

AU - Sanvisens, A.

AU - Domínguez, J.

AU - Tor, J.

AU - Prat, C.

AU - Rey-Joly, C.

AU - Muga, R.

PY - 2009/9/14

Y1 - 2009/9/14

N2 - In vitro tests have been developed for the diagnosis of tuberculosis (TB) infection. The objective was to analyse latent TB infection in drug and alcohol abusers through two interferon-γ techniques. One hundred and thirty-nine patients were admitted between February 2006 and May 2007. Mean age was 39.8 years [31% HIV positive]. The enzyme immunoassay (EIA) and enzyme-linked immunospot (ELISPOT) interferon- γ assays were positive in 34% of patients with an agreement of 83% (κ = 0.63). Tuberculin skin test (TST) was positive in 29% of patients and the agreement of TST with EIA and ELISPOT interferon- γ assays was 85% (κ = 0.62) and 83% (κ=0.57), respectively. Almost 50% of patients with history of TB had a positive in vitro test. In conclusion, we observed a high prevalence of latent TB and good agreement between the new in vitro tests that otherwise may continue to be positive long after developing TB disease. © 2009 Cambridge University Press.

AB - In vitro tests have been developed for the diagnosis of tuberculosis (TB) infection. The objective was to analyse latent TB infection in drug and alcohol abusers through two interferon-γ techniques. One hundred and thirty-nine patients were admitted between February 2006 and May 2007. Mean age was 39.8 years [31% HIV positive]. The enzyme immunoassay (EIA) and enzyme-linked immunospot (ELISPOT) interferon- γ assays were positive in 34% of patients with an agreement of 83% (κ = 0.63). Tuberculin skin test (TST) was positive in 29% of patients and the agreement of TST with EIA and ELISPOT interferon- γ assays was 85% (κ = 0.62) and 83% (κ=0.57), respectively. Almost 50% of patients with history of TB had a positive in vitro test. In conclusion, we observed a high prevalence of latent TB and good agreement between the new in vitro tests that otherwise may continue to be positive long after developing TB disease. © 2009 Cambridge University Press.

KW - Diagnosis of infection

KW - Drug abuse

KW - Interferon-γ

KW - Tuberculosis

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DO - 10.1017/S0950268809002131

M3 - Article

VL - 137

SP - 1342

EP - 1347

JO - Epidemiology and Infection

JF - Epidemiology and Infection

SN - 0950-2688

IS - 9

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