Propafenone kinetics in the horse. Comparative analysis of compartmental and noncompartmental models

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    Abstract

    The propafenone kinetics after intravenous (i.v.) administration have been studied in the horse by a comparative analysis of compartmental and noncompartmental models. The pharmacokinetic parameters showed a large distribution (Vdss = 1021 ± 211 L) and a high clearance (Cl = 7019 ± 1746 mL/min) of the drug. The plasma concentrations were very low, under 1 μg/mL, in most cases; after 30 min these concentrations can be considered as nonefficient for the treatment of arrhythmia. There were no significant differences between pharmacokinetic parameters found with the use of compartmental and noncompartmental models. © 1990.
    Original languageEnglish
    Pages (from-to)79-85
    JournalJournal of Pharmacological Methods
    Volume23
    Issue number2
    DOIs
    Publication statusPublished - 1 Jan 1990

    Keywords

    • Compartmental and noncompartmental models
    • Horse
    • Pharmacokinetics
    • Propafenone

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