Propafenone kinetics in the horse. Comparative analysis of compartmental and noncompartmental models

Anna Puigdemont; Josep Lluis Riu; Raimon Guitart; Margarita Arboix

doi:10.1016/0160-5402(90)90035-J

Propafenone kinetics in the horse. Comparative analysis of compartmental and noncompartmental models

Anna Puigdemont, Josep Lluis Riu, Raimon Guitart, Margarita Arboix

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

The propafenone kinetics after intravenous (i.v.) administration have been studied in the horse by a comparative analysis of compartmental and noncompartmental models. The pharmacokinetic parameters showed a large distribution (Vdss = 1021 ± 211 L) and a high clearance (Cl = 7019 ± 1746 mL/min) of the drug. The plasma concentrations were very low, under 1 μg/mL, in most cases; after 30 min these concentrations can be considered as nonefficient for the treatment of arrhythmia. There were no significant differences between pharmacokinetic parameters found with the use of compartmental and noncompartmental models. © 1990.

Original language	English
Pages (from-to)	79-85
Journal	Journal of Pharmacological Methods
Volume	23
Issue number	2
DOIs	https://doi.org/10.1016/0160-5402(90)90035-J
Publication status	Published - 1 Jan 1990

Keywords

Compartmental and noncompartmental models
Horse
Pharmacokinetics
Propafenone

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title = "Propafenone kinetics in the horse. Comparative analysis of compartmental and noncompartmental models",

abstract = "The propafenone kinetics after intravenous (i.v.) administration have been studied in the horse by a comparative analysis of compartmental and noncompartmental models. The pharmacokinetic parameters showed a large distribution (Vdss = 1021 ± 211 L) and a high clearance (Cl = 7019 ± 1746 mL/min) of the drug. The plasma concentrations were very low, under 1 μg/mL, in most cases; after 30 min these concentrations can be considered as nonefficient for the treatment of arrhythmia. There were no significant differences between pharmacokinetic parameters found with the use of compartmental and noncompartmental models. {\textcopyright} 1990.",

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AU - Riu, Josep Lluis

AU - Guitart, Raimon

AU - Arboix, Margarita

PY - 1990/1/1

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N2 - The propafenone kinetics after intravenous (i.v.) administration have been studied in the horse by a comparative analysis of compartmental and noncompartmental models. The pharmacokinetic parameters showed a large distribution (Vdss = 1021 ± 211 L) and a high clearance (Cl = 7019 ± 1746 mL/min) of the drug. The plasma concentrations were very low, under 1 μg/mL, in most cases; after 30 min these concentrations can be considered as nonefficient for the treatment of arrhythmia. There were no significant differences between pharmacokinetic parameters found with the use of compartmental and noncompartmental models. © 1990.

AB - The propafenone kinetics after intravenous (i.v.) administration have been studied in the horse by a comparative analysis of compartmental and noncompartmental models. The pharmacokinetic parameters showed a large distribution (Vdss = 1021 ± 211 L) and a high clearance (Cl = 7019 ± 1746 mL/min) of the drug. The plasma concentrations were very low, under 1 μg/mL, in most cases; after 30 min these concentrations can be considered as nonefficient for the treatment of arrhythmia. There were no significant differences between pharmacokinetic parameters found with the use of compartmental and noncompartmental models. © 1990.

KW - Compartmental and noncompartmental models

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KW - Pharmacokinetics

KW - Propafenone

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