Gemma Arroyo obtained her degree in Biology from the Universidad de Barcelona, and her Master's degree in Reproductive Biology and Assisted Reproduction Techniques in 1999 from the Institut Universitari Dexeus - Universitat Autònoma de Barcelona. She also has a BSc in Cellular Biology (2003) from the Universität Autònoma de Barcelona. She has been working at the IVF laboratory at Institut Universitari Dexeus since 1999. She is an active member of the Association for the Study of Reproductive Biology and the Spanish Society of Fertility. Her main interest is focused on oocyte maturation in vitro, and oocyte and early embryo morphology. Abstract The aim of the present study was to evaluate the usefulness of pronuclear patterns, according to the classifications of Tesarik and Scott, as predictors of embryo chromosome constitution. Up to 73 preimplantation genetic diagnosis/ preimplantation genetic screening (PGD/PGS) cycles were analysed in this retrospective study including 17 cycles of translocation carriers and 56 PGS cycles. A total of 331 biopsied embryos were studied assessing pronuclear (PN) pattern, embryo quality and chromosome constitution. As regards to the relationship between PN pattern and embryo quality, the data obtained in this study show no correlation between both parameters. Although there were no significant differences when comparing the distribution of chromosomally normal and abnormal embryos with respect to embryo quality, such differences were observed when distinguishing between normal, aneuploid and polyploid embryos. The results show that the PN pattern using Tesarik's and Scott's classification systems is not related to the embryo developmental potential or its chromosome constitution. Therefore, in the context of a PGD/PGS programme, the PN pattern cannot be used as a tool to predict embryo quality or chromosome status. © 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
|Journal||Reproductive BioMedicine on Line|
|Publication status||Published - 1 Jan 2010|
- Chromosome abnormalities
- Embryo quality
- Pronuclear pattern
Santalo Pedro, J., Arroyo, G., Veiga, A., & Barri, P. N. (2010). Pronuclear morphology, embryo development and chromosome constitution. Reproductive BioMedicine on Line, 20(5), 649-655. https://doi.org/10.1016/j.rbmo.2009.12.028