Progressive presynaptic dopaminergic deterioration in Huntington disease: a [123I]-FP-CIT SPECT two-year follow-up study.

Josep Gamez, Carles Lorenzo-Bosquet, Gemma Cuberas-Borrós, Francesc Carmona, Mercedes Badía, Joaquin Castilló, Mercedes Badía, Oriol de Fabregues, Jorge Hernández-Vara, Joan Castell-Conesa

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6 Citations (Scopus)

Abstract

To illustrate the potential of [I]-FP-CIT SPECT DaTSCAN® in investigating the progression of presynaptic dopaminergic degeneration in Huntington disease (HD), we performed a 2-year follow-up [I]-FP-CIT study on 4 HD patients, evaluating the SPECT imaging based on qualitative and semiquantitative analysis. The mean annual decline in [I]-FP-CIT uptake in caudate and putamen after 2 years of follow-up was 5.8% and 9.6%, respectively. Our findings suggest that [I]-FP-CIT SPECT is useful in investigating the progression of presynaptic dopaminergic degeneration in HD, and may be useful as a disease biomarker, providing an objective method for measuring the effectiveness of future neuroprotective therapies.
Original languageEnglish
JournalClinical Nuclear Medicine
Volume39
Issue number3
Publication statusPublished - 1 Jan 2014

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