Prognostic value of stem cell markers in glioblastoma

Francesc Alameda, José María Velarde, Cristina Carrato, Noemí Vidal, Montserrat Arumí, Dolores Naranjo, Maria Martinez-Garcia, Teresa Ribalta, Carme Balañá

Research output: Contribution to journalArticleResearch

2 Citations (Scopus)

Abstract

© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Background/Context: Glioblastoma (GB) is the most common primary brain tumour in adults and it is associated with a high mortality rate. According to the stem cell theory, the growth, relapse and treatment response of GB is determined by the stem cell subpopulation present in the tumour. Objective: Our aim is to study the prognostic value of stem cell markers (CD44, Nestin, Olig2 and SOX2) in a series of homogeneously treated GBs. Material and methods: We study 280 GBs treated with STUPP acheme with a histologican review of the cases and TMA with a máximum of 4 spots for each case. Each slide was immunohistochemically stained and Reading. We compared the immunohistochemical results with survival tme. Results: Only SOX2 immunoexpression (IE) excedding 10% of the tumour cells was found to be related to good survival (p= 0.037) in univariate analysis. However, amultivariate analysis indicate the age, surgery and MGMT promotes methylation but no SOX2 IE are prognostic factors. Conclusions: We conclude the immunohistochemical studies of stem cell markers in GB are not useful for predicting prognosis in daily practice.
Original languageEnglish
Pages (from-to)677-683
JournalBiomarkers
Volume24
DOIs
Publication statusPublished - 3 Oct 2019

Keywords

  • CD44
  • Glioblastoma
  • Nestin
  • Olig2
  • prognosis
  • SOX2

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    Alameda, F., Velarde, J. M., Carrato, C., Vidal, N., Arumí, M., Naranjo, D., Martinez-Garcia, M., Ribalta, T., & Balañá, C. (2019). Prognostic value of stem cell markers in glioblastoma. Biomarkers, 24, 677-683. https://doi.org/10.1080/1354750X.2019.1652345