Prognostic value of myocardial perfusion gated SPECT in patients with symptomatic intracranial large-artery atherosclerosis

J. Candell-Riera, J. F. Arenillas, G. Romero-Farina, S. Aguadé-Bruix, G. De León, J. Castell-Conesa, C. A. Molina, A. Rovira, J. Álvarez-Sabín

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5 Citations (Scopus)

Abstract

Background: We aimed to evaluate the prognostic value of myocardial perfusion gated SPECT in patients with symptomatic intracranial large-artery atherosclerosis (ILA). Methods: Seventy-two consecutive first-ever symptomatic ILA patients without known heart disease underwent a stress myocardial perfusion gated SPECT, and long-term follow-up was conducted thereafter. Results: During an average follow-up of 15.2 ± 9 months, 9 patients (13.8%) presented major coronary events (CEs). Survival analyses (Kaplan-Meier and Cox regression) identified presence of moderate-to-severe myocardial perfusion defects (log rank p = 0.004) and ejection fraction <50% (p = 0.014) as predictors of future CEs. Neurovascular ischemic events were not predicted by SPECT variables. Conclusion: Myocardial perfusion scintigraphy predicts future CEs in patients with symptomatic ILA and may be helpful to guide therapeutic strategies in this subgroup of stroke patients. Copyright © 2007 S. Karger AG.
Original languageEnglish
Pages (from-to)247-254
JournalCerebrovascular Diseases
Volume24
Issue number2-3
DOIs
Publication statusPublished - 1 Aug 2007

Keywords

  • Gated single-photon emission computed tomography
  • Intracranial atherosclerosis
  • Intracranial stenosis
  • Myocardial ischemia

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