Prognostic value of CD45 transcriptional expression in head and neck cancer

Mercedes Camacho, Adriana Agüero, Anna Sumarroca, Laura López, Miguel Ángel Pavón, Francesc Xavier Avilés-Jurado, Jacinto García, Miquel Quer, Xavier León

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

© 2017, Springer-Verlag GmbH Germany, part of Springer Nature. Introduction: Tumor-infiltrating lymphocytes (TILs) have a recognized antitumor activity in head and neck squamous cell carcinoma (HNSCC). CD45 is one of the most highly expressed proteins in lymphocytes. We carry out a study to assess the prognostic value of transcriptional expression of CD45 in HNSCC. Material and methods: We determined the transcriptional expression of CD45 in 160 consecutive HNSCC patients and compared the TIL values according to the CD45 expression. Results: Five-year disease-free survival for patients with a high transcriptional expression of CD45 (n = 107) was 62.4% and for patients with a low expression (n = 53) it was 36.2% (P = 0.003). Patients with a high expression of CD45 had a better local recurrence-free survival and disease-specific survival. The results of a multivariate analysis showed that patients with a low expression of CD45 had 2.0-fold high risk of recurrence (95% CI 1.2–3.2, P = 0.003). In oropharyngeal carcinomas, HPV-positive tumors showed a higher transcriptional CD45 expression than HPV-negative tumors. Tumors with high CD45 expression had immunohistochemical TIL scores significantly higher than those with low CD45 expression. Conclusion: According to our results, CD45 expression is a potential marker for tumor outcome in HNSCC patients.
Original languageEnglish
Pages (from-to)225-232
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume275
Issue number1
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • CD45
  • Head and neck squamous cell carcinoma
  • Immune infiltrate
  • Transcriptional expression
  • Tumor-infiltrating lymphocytes

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