Prognostic role of tapse to pasp ratio in patients undergoing mitraclip procedure

Dabit Arzamendi; Blanca Trejo-Velasco; Rodrigo Estevez-Loureiro; Fernando Carrasco-Chinchilla; Felipe Fernández-Vázquez; Manuel Pan Álvarez-Ossorio; Isaac Pascual; Luís Nombela-Franco; Ignacio J Amat-Santos; Xavier Freixa; Rosa Ana Hernández-Antolín; Ramiro Trillo-Nouche; L.A. Ikazuriaga; J.R. López-Mínguez; Dario Sanmiguel Cervera; Juan Sanchis; José Luís Diez-Gil; Valeriano Ruiz-Quevedo; Cristóbal A. Urbano-Carrillo; Víctor M. Becerra-Muñoz; Tomás Benito-González; Chi Hion Li; Dolores Mesa; Pablo Avanzas; Germán Armijo; Ana María Serrador-Frutos; Laura Sanchis; Covadonga Fernández-Golfín; Belén Cid-Álvarez; José María Hernández-García; Carmen Garrote-Coloma; Estefanía Fernández-Peregrina; Miguel A. Romero; Víctor León Argüero; Ignacio Cruz-González

doi:10.3390/jcm10051006

Prognostic role of tapse to pasp ratio in patients undergoing mitraclip procedure

Dabit Arzamendi, Blanca Trejo-Velasco, Rodrigo Estevez-Loureiro, Fernando Carrasco-Chinchilla, Felipe Fernández-Vázquez, Manuel Pan Álvarez-Ossorio, Isaac Pascual, Luís Nombela-Franco, Ignacio J Amat-Santos, Xavier Freixa, Rosa Ana Hernández-Antolín, Ramiro Trillo-Nouche, L.A. Ikazuriaga, J.R. López-Mínguez, Dario Sanmiguel Cervera, Juan Sanchis, José Luís Diez-Gil, Valeriano Ruiz-Quevedo, Cristóbal A. Urbano-Carrillo, Víctor M. Becerra-MuñozTomás Benito-González, Chi Hion Li, Dolores Mesa, Pablo Avanzas, Germán Armijo, Ana María Serrador-Frutos, Laura Sanchis, Covadonga Fernández-Golfín, Belén Cid-Álvarez, José María Hernández-García, Carmen Garrote-Coloma, Estefanía Fernández-Peregrina, Miguel A. Romero, Víctor León Argüero, Ignacio Cruz-González

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

17 Citations (Scopus)

Abstract

Background: Transcatheter mitral valve repair (TMVR) is an effective therapy for high-risk patients with severe mitral regurgitation (MR) but heart failure (HF) readmissions and death remain substantial on mid-term follow-up. Recently, right ventricular (RV) to pulmonary arterial (PA) coupling has emerged as a relevant prognostic predictor in HF. In this study, we aimed to assess the prognostic value of tricuspid annular plane systolic excursion (TAPSE) to PA systolic pressure (PASP) ratio as a non-invasive measure of RV-to-PA coupling in patients undergoing TMVR with MitraClip (Abbott, CA, USA). Methods: Multicentre registry including 228 consecutive patients that underwent successful TMVR with MitraClip. The sample was divided in two groups according to TAPSE/PASP median value: 0.35. The primary combined endpoint encompassed HF readmissions and all-cause mortality. Results: Mean age was 72.5 ± 11.5 years and 154 (67.5%) patients were male. HF readmissions and all-cause mortality were more frequent in patients with TAPSE/PASP ≤ 0.35: Log-Rank 8.844, p = 0.003. On Cox regression, TAPSE/PASP emerged as a prognostic predictor of the primary combined endpoint, together with STS-Score. TAPSE/PASP was a better prognostic predictor than either TAPSE or PASP separately. Conclusions: TAPSE/PASP ratio appears as a novel prognostic predictor in patients undergoing MitraClip implantation that might improve risk stratification and candidate selection.

Original language	English
Pages (from-to)	1-13
Number of pages	13
Journal	Journal of Clinical Medicine
Volume	10
Issue number	5
DOIs	https://doi.org/10.3390/jcm10051006
Publication status	Published - 2021

Keywords

MitraClip
Mitral valve repair
Mitral valve regurgitation
Pulmonary hypertension
Right ventricular to pulmonary arterial coupling
Transthoracic echocardiography

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10.3390/jcm10051006

https://ddd.uab.cat/record/272101Licence: CC BY

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Arzamendi, D., Trejo-Velasco, B., Estevez-Loureiro, R., Carrasco-Chinchilla, F., Fernández-Vázquez, F., Pan Álvarez-Ossorio, M., Pascual, I., Nombela-Franco, L., Amat-Santos, I. J., Freixa, X., Hernández-Antolín, R. A., Trillo-Nouche, R., Ikazuriaga, L. A., López-Mínguez, J. R., Cervera, D. S., Sanchis, J., Diez-Gil, J. L., Ruiz-Quevedo, V., Urbano-Carrillo, C. A., ... Cruz-González, I. (2021). Prognostic role of tapse to pasp ratio in patients undergoing mitraclip procedure. Journal of Clinical Medicine, 10(5), 1-13. https://doi.org/10.3390/jcm10051006

@article{bd5c9cfedf234963b425168d93040867,

title = "Prognostic role of tapse to pasp ratio in patients undergoing mitraclip procedure",

abstract = "Background: Transcatheter mitral valve repair (TMVR) is an effective therapy for high-risk patients with severe mitral regurgitation (MR) but heart failure (HF) readmissions and death remain substantial on mid-term follow-up. Recently, right ventricular (RV) to pulmonary arterial (PA) coupling has emerged as a relevant prognostic predictor in HF. In this study, we aimed to assess the prognostic value of tricuspid annular plane systolic excursion (TAPSE) to PA systolic pressure (PASP) ratio as a non-invasive measure of RV-to-PA coupling in patients undergoing TMVR with MitraClip (Abbott, CA, USA). Methods: Multicentre registry including 228 consecutive patients that underwent successful TMVR with MitraClip. The sample was divided in two groups according to TAPSE/PASP median value: 0.35. The primary combined endpoint encompassed HF readmissions and all-cause mortality. Results: Mean age was 72.5 ± 11.5 years and 154 (67.5%) patients were male. HF readmissions and all-cause mortality were more frequent in patients with TAPSE/PASP ≤ 0.35: Log-Rank 8.844, p = 0.003. On Cox regression, TAPSE/PASP emerged as a prognostic predictor of the primary combined endpoint, together with STS-Score. TAPSE/PASP was a better prognostic predictor than either TAPSE or PASP separately. Conclusions: TAPSE/PASP ratio appears as a novel prognostic predictor in patients undergoing MitraClip implantation that might improve risk stratification and candidate selection.",

keywords = "MitraClip, Mitral valve repair, Mitral valve regurgitation, Pulmonary hypertension, Right ventricular to pulmonary arterial coupling, Transthoracic echocardiography",

author = "Dabit Arzamendi and Blanca Trejo-Velasco and Rodrigo Estevez-Loureiro and Fernando Carrasco-Chinchilla and Felipe Fern{\'a}ndez-V{\'a}zquez and {Pan {\'A}lvarez-Ossorio}, Manuel and Isaac Pascual and Lu{\'i}s Nombela-Franco and Amat-Santos, {Ignacio J} and Xavier Freixa and Hern{\'a}ndez-Antol{\'i}n, {Rosa Ana} and Ramiro Trillo-Nouche and L.A. Ikazuriaga and J.R. L{\'o}pez-M{\'i}nguez and Cervera, {Dario Sanmiguel} and Juan Sanchis and Diez-Gil, {Jos{\'e} Lu{\'i}s} and Valeriano Ruiz-Quevedo and Urbano-Carrillo, {Crist{\'o}bal A.} and Becerra-Mu{\~n}oz, {V{\'i}ctor M.} and Tom{\'a}s Benito-Gonz{\'a}lez and Li, {Chi Hion} and Dolores Mesa and Pablo Avanzas and Germ{\'a}n Armijo and Serrador-Frutos, {Ana Mar{\'i}a} and Laura Sanchis and Covadonga Fern{\'a}ndez-Golf{\'i}n and Bel{\'e}n Cid-{\'A}lvarez and Hern{\'a}ndez-Garc{\'i}a, {Jos{\'e} Mar{\'i}a} and Carmen Garrote-Coloma and Estefan{\'i}a Fern{\'a}ndez-Peregrina and Romero, {Miguel A.} and Arg{\"u}ero, {V{\'i}ctor Le{\'o}n} and Ignacio Cruz-Gonz{\'a}lez",

year = "2021",

doi = "10.3390/jcm10051006",

language = "English",

volume = "10",

pages = "1--13",

number = "5",

}

Arzamendi, D, Trejo-Velasco, B, Estevez-Loureiro, R, Carrasco-Chinchilla, F, Fernández-Vázquez, F, Pan Álvarez-Ossorio, M, Pascual, I, Nombela-Franco, L, Amat-Santos, IJ, Freixa, X, Hernández-Antolín, RA, Trillo-Nouche, R, Ikazuriaga, LA, López-Mínguez, JR, Cervera, DS, Sanchis, J, Diez-Gil, JL, Ruiz-Quevedo, V, Urbano-Carrillo, CA, Becerra-Muñoz, VM, Benito-González, T, Li, CH, Mesa, D, Avanzas, P, Armijo, G, Serrador-Frutos, AM, Sanchis, L, Fernández-Golfín, C, Cid-Álvarez, B, Hernández-García, JM, Garrote-Coloma, C, Fernández-Peregrina, E, Romero, MA, Argüero, VL & Cruz-González, I 2021, 'Prognostic role of tapse to pasp ratio in patients undergoing mitraclip procedure', Journal of Clinical Medicine, vol. 10, no. 5, pp. 1-13. https://doi.org/10.3390/jcm10051006

TY - JOUR

T1 - Prognostic role of tapse to pasp ratio in patients undergoing mitraclip procedure

AU - Arzamendi, Dabit

AU - Trejo-Velasco, Blanca

AU - Estevez-Loureiro, Rodrigo

AU - Carrasco-Chinchilla, Fernando

AU - Fernández-Vázquez, Felipe

AU - Pan Álvarez-Ossorio, Manuel

AU - Pascual, Isaac

AU - Nombela-Franco, Luís

AU - Amat-Santos, Ignacio J

AU - Freixa, Xavier

AU - Hernández-Antolín, Rosa Ana

AU - Trillo-Nouche, Ramiro

AU - Ikazuriaga, L.A.

AU - López-Mínguez, J.R.

AU - Cervera, Dario Sanmiguel

AU - Sanchis, Juan

AU - Diez-Gil, José Luís

AU - Ruiz-Quevedo, Valeriano

AU - Urbano-Carrillo, Cristóbal A.

AU - Becerra-Muñoz, Víctor M.

AU - Benito-González, Tomás

AU - Li, Chi Hion

AU - Mesa, Dolores

AU - Avanzas, Pablo

AU - Armijo, Germán

AU - Serrador-Frutos, Ana María

AU - Sanchis, Laura

AU - Fernández-Golfín, Covadonga

AU - Cid-Álvarez, Belén

AU - Hernández-García, José María

AU - Garrote-Coloma, Carmen

AU - Fernández-Peregrina, Estefanía

AU - Romero, Miguel A.

AU - Argüero, Víctor León

AU - Cruz-González, Ignacio

PY - 2021

Y1 - 2021

N2 - Background: Transcatheter mitral valve repair (TMVR) is an effective therapy for high-risk patients with severe mitral regurgitation (MR) but heart failure (HF) readmissions and death remain substantial on mid-term follow-up. Recently, right ventricular (RV) to pulmonary arterial (PA) coupling has emerged as a relevant prognostic predictor in HF. In this study, we aimed to assess the prognostic value of tricuspid annular plane systolic excursion (TAPSE) to PA systolic pressure (PASP) ratio as a non-invasive measure of RV-to-PA coupling in patients undergoing TMVR with MitraClip (Abbott, CA, USA). Methods: Multicentre registry including 228 consecutive patients that underwent successful TMVR with MitraClip. The sample was divided in two groups according to TAPSE/PASP median value: 0.35. The primary combined endpoint encompassed HF readmissions and all-cause mortality. Results: Mean age was 72.5 ± 11.5 years and 154 (67.5%) patients were male. HF readmissions and all-cause mortality were more frequent in patients with TAPSE/PASP ≤ 0.35: Log-Rank 8.844, p = 0.003. On Cox regression, TAPSE/PASP emerged as a prognostic predictor of the primary combined endpoint, together with STS-Score. TAPSE/PASP was a better prognostic predictor than either TAPSE or PASP separately. Conclusions: TAPSE/PASP ratio appears as a novel prognostic predictor in patients undergoing MitraClip implantation that might improve risk stratification and candidate selection.

AB - Background: Transcatheter mitral valve repair (TMVR) is an effective therapy for high-risk patients with severe mitral regurgitation (MR) but heart failure (HF) readmissions and death remain substantial on mid-term follow-up. Recently, right ventricular (RV) to pulmonary arterial (PA) coupling has emerged as a relevant prognostic predictor in HF. In this study, we aimed to assess the prognostic value of tricuspid annular plane systolic excursion (TAPSE) to PA systolic pressure (PASP) ratio as a non-invasive measure of RV-to-PA coupling in patients undergoing TMVR with MitraClip (Abbott, CA, USA). Methods: Multicentre registry including 228 consecutive patients that underwent successful TMVR with MitraClip. The sample was divided in two groups according to TAPSE/PASP median value: 0.35. The primary combined endpoint encompassed HF readmissions and all-cause mortality. Results: Mean age was 72.5 ± 11.5 years and 154 (67.5%) patients were male. HF readmissions and all-cause mortality were more frequent in patients with TAPSE/PASP ≤ 0.35: Log-Rank 8.844, p = 0.003. On Cox regression, TAPSE/PASP emerged as a prognostic predictor of the primary combined endpoint, together with STS-Score. TAPSE/PASP was a better prognostic predictor than either TAPSE or PASP separately. Conclusions: TAPSE/PASP ratio appears as a novel prognostic predictor in patients undergoing MitraClip implantation that might improve risk stratification and candidate selection.

KW - MitraClip

KW - Mitral valve repair

KW - Mitral valve regurgitation

KW - Pulmonary hypertension

KW - Right ventricular to pulmonary arterial coupling

KW - Transthoracic echocardiography

U2 - 10.3390/jcm10051006

DO - 10.3390/jcm10051006

M3 - Article

C2 - 33801311

SN - 2077-0383

VL - 10

SP - 1

EP - 13

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 5

ER -

Prognostic role of tapse to pasp ratio in patients undergoing mitraclip procedure

Abstract

Keywords

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