Prognostic role of intraparotid lymph node metastasis in primary parotid cancer :: Systematic review

Orlando Guntinas-Lichius; Jovanna Thielker; K.Thomas Robbins; Kerry D. Olsen; Ashok R. Shaha; Antti A. Mäkitie; Remco de Bree; Vincent Vander Poorten; Miquel Quer; Alessandra Rinaldo; Luiz Paulo Kowalski; Juan Pablo Rodrigo; Marc Hamoir; Alfio Ferlito

doi:10.1002/hed.26541

Prognostic role of intraparotid lymph node metastasis in primary parotid cancer : Systematic review

Orlando Guntinas-Lichius, Jovanna Thielker, K.Thomas Robbins, Kerry D. Olsen, Ashok R. Shaha, Antti A. Mäkitie, Remco de Bree, Vincent Vander Poorten, Miquel Quer, Alessandra Rinaldo, Luiz Paulo Kowalski, Juan Pablo Rodrigo, Marc Hamoir, Alfio Ferlito

Department of Surgery

Research output: Contribution to journal › Review article › Research › peer-review

28 Citations (Scopus)

Abstract

Background: The prognostic importance of intraparotid lymph node metastasis (P+) in patients with primary parotid gland carcinoma is unclear. Methods: Nineteen retrospective and noncomparative cohort studies, published between 1992 and 2020, met the inclusion criteria and included 2202 patients for this systematic review. Results: The pooled prevalence of the P in adult patients in the unselected studies was 24.10% (95% confidence interval = 17.95-30.25). The number of P+ lymph nodes per patient was counted in only three studies and ranged from 1 to 11. The 5-year recurrence-free survival rate based on Kaplan-Meier analysis varied from 83% to 88% in P− patients compared to 36% to 54% in P+ patients. The average hazard ratio for tumor recurrence in patients with P+ compared to P− was 2.67 ± 0.58. Conclusions: P+ is an independent negative prognostic factor in primary parotid gland cancer and should be included into the treatment planning.

Original language	English
Pages (from-to)	997-1008
Number of pages	12
Journal	Head and Neck
Volume	43
Issue number	3
DOIs	https://doi.org/10.1002/hed.26541
Publication status	Published - 2021

Keywords

Clinical significance
Intraparotid lymph node metastasis
Nodal metastasis
Prevalence
Primary parotid cancer
Survival

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/hed.26541

https://ddd.uab.cat/record/272095

Cite this

Guntinas-Lichius, O., Thielker, J., Robbins, K. T., Olsen, K. D., Shaha, A. R., Mäkitie, A. A., de Bree, R., Vander Poorten, V., Quer, M., Rinaldo, A., Kowalski, L. P., Rodrigo, J. P., Hamoir, M., & Ferlito, A. (2021). Prognostic role of intraparotid lymph node metastasis in primary parotid cancer : Systematic review. Head and Neck, 43(3), 997-1008. https://doi.org/10.1002/hed.26541

@article{ffbe776515b04123a4dd9e6b9717828c,

title = "Prognostic role of intraparotid lymph node metastasis in primary parotid cancer :: Systematic review",

abstract = "Background: The prognostic importance of intraparotid lymph node metastasis (P+) in patients with primary parotid gland carcinoma is unclear. Methods: Nineteen retrospective and noncomparative cohort studies, published between 1992 and 2020, met the inclusion criteria and included 2202 patients for this systematic review. Results: The pooled prevalence of the P in adult patients in the unselected studies was 24.10% (95% confidence interval = 17.95-30.25). The number of P+ lymph nodes per patient was counted in only three studies and ranged from 1 to 11. The 5-year recurrence-free survival rate based on Kaplan-Meier analysis varied from 83% to 88% in P− patients compared to 36% to 54% in P+ patients. The average hazard ratio for tumor recurrence in patients with P+ compared to P− was 2.67 ± 0.58. Conclusions: P+ is an independent negative prognostic factor in primary parotid gland cancer and should be included into the treatment planning.",

keywords = "Clinical significance, Intraparotid lymph node metastasis, Nodal metastasis, Prevalence, Primary parotid cancer, Survival",

author = "Orlando Guntinas-Lichius and Jovanna Thielker and K.Thomas Robbins and Olsen, {Kerry D.} and Shaha, {Ashok R.} and M{\"a}kitie, {Antti A.} and {de Bree}, Remco and {Vander Poorten}, Vincent and Miquel Quer and Alessandra Rinaldo and Kowalski, {Luiz Paulo} and Rodrigo, {Juan Pablo} and Marc Hamoir and Alfio Ferlito",

year = "2021",

doi = "10.1002/hed.26541",

language = "English",

volume = "43",

pages = "997--1008",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley and Sons Inc.",

number = "3",

}

Guntinas-Lichius, O, Thielker, J, Robbins, KT, Olsen, KD, Shaha, AR, Mäkitie, AA, de Bree, R, Vander Poorten, V, Quer, M, Rinaldo, A, Kowalski, LP, Rodrigo, JP, Hamoir, M & Ferlito, A 2021, 'Prognostic role of intraparotid lymph node metastasis in primary parotid cancer : Systematic review', Head and Neck, vol. 43, no. 3, pp. 997-1008. https://doi.org/10.1002/hed.26541

TY - JOUR

T1 - Prognostic role of intraparotid lymph node metastasis in primary parotid cancer :

T2 - Systematic review

AU - Guntinas-Lichius, Orlando

AU - Thielker, Jovanna

AU - Robbins, K.Thomas

AU - Olsen, Kerry D.

AU - Shaha, Ashok R.

AU - Mäkitie, Antti A.

AU - de Bree, Remco

AU - Vander Poorten, Vincent

AU - Quer, Miquel

AU - Rinaldo, Alessandra

AU - Kowalski, Luiz Paulo

AU - Rodrigo, Juan Pablo

AU - Hamoir, Marc

AU - Ferlito, Alfio

PY - 2021

Y1 - 2021

N2 - Background: The prognostic importance of intraparotid lymph node metastasis (P+) in patients with primary parotid gland carcinoma is unclear. Methods: Nineteen retrospective and noncomparative cohort studies, published between 1992 and 2020, met the inclusion criteria and included 2202 patients for this systematic review. Results: The pooled prevalence of the P in adult patients in the unselected studies was 24.10% (95% confidence interval = 17.95-30.25). The number of P+ lymph nodes per patient was counted in only three studies and ranged from 1 to 11. The 5-year recurrence-free survival rate based on Kaplan-Meier analysis varied from 83% to 88% in P− patients compared to 36% to 54% in P+ patients. The average hazard ratio for tumor recurrence in patients with P+ compared to P− was 2.67 ± 0.58. Conclusions: P+ is an independent negative prognostic factor in primary parotid gland cancer and should be included into the treatment planning.

AB - Background: The prognostic importance of intraparotid lymph node metastasis (P+) in patients with primary parotid gland carcinoma is unclear. Methods: Nineteen retrospective and noncomparative cohort studies, published between 1992 and 2020, met the inclusion criteria and included 2202 patients for this systematic review. Results: The pooled prevalence of the P in adult patients in the unselected studies was 24.10% (95% confidence interval = 17.95-30.25). The number of P+ lymph nodes per patient was counted in only three studies and ranged from 1 to 11. The 5-year recurrence-free survival rate based on Kaplan-Meier analysis varied from 83% to 88% in P− patients compared to 36% to 54% in P+ patients. The average hazard ratio for tumor recurrence in patients with P+ compared to P− was 2.67 ± 0.58. Conclusions: P+ is an independent negative prognostic factor in primary parotid gland cancer and should be included into the treatment planning.

KW - Clinical significance

KW - Intraparotid lymph node metastasis

KW - Nodal metastasis

KW - Prevalence

KW - Primary parotid cancer

KW - Survival

U2 - 10.1002/hed.26541

DO - 10.1002/hed.26541

M3 - Review article

C2 - 33169420

SN - 1043-3074

VL - 43

SP - 997

EP - 1008

JO - Head and Neck

JF - Head and Neck

IS - 3

ER -