Implicación pronóstica de la fragilidad y los síntomas depresivos en una población ambulatoria con insuficiencia cardiaca

Translated title of the contribution: Prognostic implication of frailty and depressive symptoms in an outpatient population with heart failure

Josep Lupón*, Beatriz González, Sebastián Santaeugenia, Salvador Altimir, Agustín Urrutia, Dolores Más, Crisanto Díez, Teresa Pascual, Lucía Cano, Vicente Valle

*Corresponding author for this work

    Research output: Contribution to journalArticleResearchpeer-review

    112 Citations (Scopus)

    Abstract

    Introduction and objectives. Heart failure patients have high levels of frailty and dependence. Our aim was to determine the impact of frailty and depressive symptoms on the 1-year mortality rate and the rate of hospitalization for heart failure during a follow-up period of 1 year. Methods. All patients underwent geriatric evaluation, and frailty and depressive symptoms were identified. The study included 622 patients (72.5% male; median age, 68 years; 92% in New York Heart Association class II or III; and median ejection fraction, 30%). Results. During follow-up, 60 patients (9.5%) died and 101 (16.2%) were hospitalized for heart failure. Overall, 39.9% of patients exhibited frailty, while 25.2% had depressive symptoms. There were significant associations between mortality at 1 year and the presence of frailty (16.9% vs. 4.8%; P<.001) and depressive symptoms (15.3% vs. 7.7%; P=.006). There was also a significant relationship between heart failure hospitalization and the presence of frailty (20.5% vs. 13.3%; P=.01). No relationship was found between heart failure hospitalization and depressive symptoms. Frailty was an independent predictor of mortality but not of hospitalization. Conclusions. Univariate analysis demonstrated significant relationships between frailty and depressive symptoms and mortality at 1 year. In addition, there was a significant relationship between frailty and the need for heart failure hospitalization. However, only frailty showed prognostic value to predict mortality, which was independent of other variables strongly associated to outcome.

    Translated title of the contributionPrognostic implication of frailty and depressive symptoms in an outpatient population with heart failure
    Original languageSpanish
    Pages (from-to)835-842
    Number of pages8
    JournalRevista Espanola de Cardiologia
    Volume61
    Issue number8
    DOIs
    Publication statusPublished - Aug 2008

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