Prognostic and predictive roles for circulating biomarkers in gastrointestinal cancer

Leticia De Mattos-Arruda; David Olmos; Josep Tabernero

doi:10.2217/fon.11.122

Prognostic and predictive roles for circulating biomarkers in gastrointestinal cancer

Leticia De Mattos-Arruda, David Olmos, Josep Tabernero

Department of Medicine

Research output: Contribution to journal › Review article › Research › peer-review

37 Citations (Scopus)

Abstract

Circulating tumor cells (CTCs) and circulating free DNA (cfDNA) have been studied as promising prognostic and predictive tumor-derived biomarkers in the bloodstream of patients with gastrointestinal malignancies because they may be an alternative noninvasive tool to tumor tissue biopsies. Quantification and molecular characterization of CTCs and cfDNA may provide additional insights into cancer biology, potentially revealing novel targets to individualize cancer care. The present article aims to review the biology and current methods to assess CTCs and cfDNA, and the efforts to establish both tumor-derived biomarkers as prognostic and predictive factors in esophageal, gastric and colorectal cancer. © 2011 Future Medicine Ltd.

Original language	English
Pages (from-to)	1385-1397
Journal	Future Oncology
Volume	7
Issue number	12
DOIs	https://doi.org/10.2217/fon.11.122
Publication status	Published - 1 Dec 2011

Keywords

biomarkers
circulating free DNA
circulating tumor cells
colorectal cancer
esophageal cancer
gastric cancer
prognostic

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/fon.11.122

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title = "Prognostic and predictive roles for circulating biomarkers in gastrointestinal cancer",

abstract = "Circulating tumor cells (CTCs) and circulating free DNA (cfDNA) have been studied as promising prognostic and predictive tumor-derived biomarkers in the bloodstream of patients with gastrointestinal malignancies because they may be an alternative noninvasive tool to tumor tissue biopsies. Quantification and molecular characterization of CTCs and cfDNA may provide additional insights into cancer biology, potentially revealing novel targets to individualize cancer care. The present article aims to review the biology and current methods to assess CTCs and cfDNA, and the efforts to establish both tumor-derived biomarkers as prognostic and predictive factors in esophageal, gastric and colorectal cancer. {\textcopyright} 2011 Future Medicine Ltd.",

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T1 - Prognostic and predictive roles for circulating biomarkers in gastrointestinal cancer

AU - De Mattos-Arruda, Leticia

AU - Olmos, David

AU - Tabernero, Josep

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Circulating tumor cells (CTCs) and circulating free DNA (cfDNA) have been studied as promising prognostic and predictive tumor-derived biomarkers in the bloodstream of patients with gastrointestinal malignancies because they may be an alternative noninvasive tool to tumor tissue biopsies. Quantification and molecular characterization of CTCs and cfDNA may provide additional insights into cancer biology, potentially revealing novel targets to individualize cancer care. The present article aims to review the biology and current methods to assess CTCs and cfDNA, and the efforts to establish both tumor-derived biomarkers as prognostic and predictive factors in esophageal, gastric and colorectal cancer. © 2011 Future Medicine Ltd.

AB - Circulating tumor cells (CTCs) and circulating free DNA (cfDNA) have been studied as promising prognostic and predictive tumor-derived biomarkers in the bloodstream of patients with gastrointestinal malignancies because they may be an alternative noninvasive tool to tumor tissue biopsies. Quantification and molecular characterization of CTCs and cfDNA may provide additional insights into cancer biology, potentially revealing novel targets to individualize cancer care. The present article aims to review the biology and current methods to assess CTCs and cfDNA, and the efforts to establish both tumor-derived biomarkers as prognostic and predictive factors in esophageal, gastric and colorectal cancer. © 2011 Future Medicine Ltd.

KW - biomarkers

KW - circulating free DNA

KW - circulating tumor cells

KW - colorectal cancer

KW - esophageal cancer

KW - gastric cancer

KW - prognostic

U2 - 10.2217/fon.11.122

DO - 10.2217/fon.11.122

M3 - Review article

SN - 1479-6694

VL - 7

SP - 1385

EP - 1397

JO - Future Oncology

JF - Future Oncology

IS - 12

ER -

Prognostic and predictive roles for circulating biomarkers in gastrointestinal cancer

Abstract

Keywords

UN SDGs

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