Prognostic and predictive roles for circulating biomarkers in gastrointestinal cancer

Leticia De Mattos-Arruda, David Olmos, Josep Tabernero

Research output: Contribution to journalReview articleResearchpeer-review

37 Citations (Scopus)


Circulating tumor cells (CTCs) and circulating free DNA (cfDNA) have been studied as promising prognostic and predictive tumor-derived biomarkers in the bloodstream of patients with gastrointestinal malignancies because they may be an alternative noninvasive tool to tumor tissue biopsies. Quantification and molecular characterization of CTCs and cfDNA may provide additional insights into cancer biology, potentially revealing novel targets to individualize cancer care. The present article aims to review the biology and current methods to assess CTCs and cfDNA, and the efforts to establish both tumor-derived biomarkers as prognostic and predictive factors in esophageal, gastric and colorectal cancer. © 2011 Future Medicine Ltd.
Original languageEnglish
Pages (from-to)1385-1397
JournalFuture Oncology
Issue number12
Publication statusPublished - 1 Dec 2011


  • biomarkers
  • circulating free DNA
  • circulating tumor cells
  • colorectal cancer
  • esophageal cancer
  • gastric cancer
  • prognostic


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