Profile of blinatumomab and its potential in the treatment of relapsed/refractory acute lymphoblastic leukemia

Josep Maria Ribera, Albert Ferrer, Jordi Ribera, Eulàlia Genescà

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Abstract

© 2015, Ribera et al. The CD19 marker is expressed on the surface of normal and malignant immature or mature B-cells. On the other hand, immunotherapy involving T-cells is a promising modality of treatment for many neoplastic diseases including leukemias and lymphomas. The CD19/CD3-bispecific T-cell-engaging (BiTE®) monoclonal antibody blinatumomab can transiently engage cytotoxic T-cells to CD19+ target B-cells inducing serial perforin-mediated lysis. In the first clinical trial, blinatumomab showed efficacy in non-Hodgkin’s lymphomas, but the most important trials have been conducted in relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL) and in ALL with minimal residual disease. Encouraging reports on the activity of blinatumomab in R/R Philadelphia chromosome-negative B-cell precursor ALL led to its approval by the US Food and Drug Administration on December 3, 2014 after an accelerated review process. This review focuses on the profile of blinatumomab and its activity in R/R ALL.
Original languageEnglish
Pages (from-to)1567-1574
JournalOncoTargets and Therapy
Volume8
DOIs
Publication statusPublished - 24 Jun 2015

Keywords

  • Acute lymphoblastic leukemia
  • BiTE® monoclonal antibodies
  • Blinatumomab
  • Relapsed/refractory

Fingerprint Dive into the research topics of 'Profile of blinatumomab and its potential in the treatment of relapsed/refractory acute lymphoblastic leukemia'. Together they form a unique fingerprint.

  • Cite this