Production of water-soluble few-layer graphene mesosheets by dry milling with hydrophobic drug

Noelia Rubio, Rui Serra-Maia, Houmam Kafa, Kuo Ching Mei, Khuloud T. Al-Jamal, William Luckhurst, Mire Zloh, Frederic Festy, Jonathan P. Richardson, Julian R. Naglik, Elzbieta Pach, Belén Ballesteros

    Research output: Contribution to journalArticleResearchpeer-review

    11 Citations (Scopus)

    Abstract

    © 2014 American Chemical Society. A novel, fast, and easy mechano-chemistry-based (dry milling) method has been developed to exfoliate graphene with hydrophobic drugs generating few-layer graphene mesosheets (< 10 nm in thickness and ∼1 μm in width). The electronic properties of the graphitic structure were partially preserved after the milling treatment compared with graphene oxide prepared by Hummers' method. Several characterization techniques such as thermogravimetric analysis, Raman spectroscopy, atomic force microscopy, electron microscopy, and molecular dynamics simulation were used to characterize this material. The drug-exfoliated mesosheets were pharmacologically inactive, offering a new approach for making water-soluble few-layer graphene mesosheets upon dry milling with hydrophobic drugs, mainly used as exfoliating agents. (Figure Presented).
    Original languageEnglish
    Pages (from-to)14999-15008
    JournalLangmuir
    Volume30
    Issue number49
    DOIs
    Publication statusPublished - 16 Dec 2014

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