Procalcitonin accurately predicts lung transplant adults with low risk of pulmonary graft dysfunction and intensive care mortality

Cristopher Mazo, Bárbara Borgatta, Teresa Pont, Alberto Sandiumenge, Silvia Moyano, Antonio Roman, Jordi Rello

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

© 2017 Elsevier Inc. Purpose: We evaluated the association of procalcitonin (PCT), IL-6-8-10 plasma levels during the first 72 h after lung transplantation (LT) with ICU-mortality, oxygenation, primary graft dysfunction (PGD), and one-year graft function after LT. Material and methods: Prospective, observational study. PCT and IL-6-8-10 plasma levels were measured at 24 h, 48 h and 72 h after LT from 100 lung transplant recipients (LTr). Patients were followed until one year after LT. End-points were ICU survival, grade 3 PGD at 72 h and one-year graft function. Results: Higher PCT at 24 h was associated with lower PaO 2 /F I O 2 ratio and Grade 3 PGD over the first 72 h after LT (p < 0.05). PCT at 24 h was higher in the 9 patients who died (2.90 vs 1.47 ng/mL, p < 0.05), with AUC = 0.74 for predicting ICU-mortality. All patients with PCT < 2 ng/mL at 24 h following LT, survived in the ICU (p < 0.05). PCT and IL-10 at 48 h were correlated with FEV 1 (rho = − 0.35) and FVC (rho = − 0.29) one year after LT. (p < 0.05). Conclusions: A breakpoint of PCT < 2 ng/mL within 24 h has a high predictive value to exclude grade 3 PGD at 72 h and for ICU survival. Moreover, both PCT and IL-10 within 48 h were associated with significantly better graft function one year after surgery.
Original languageEnglish
Pages (from-to)142-147
JournalJournal of Critical Care
Volume44
DOIs
Publication statusPublished - 1 Apr 2018

Keywords

  • Biomarkers
  • Lung transplantation
  • Mortality
  • Primary graft dysfunction
  • Procalcitonin

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