Primitive neuroectodermal tumor of the central nervous system with glial differentiation: A FISH study of an adult case

F. Alameda, J. Lloreta, A. Ariza, M. Salido, B. Espinet, T. Baro, G. Garcia-Fructoso, E. Galito, A. Munne, F. F. Cruz Sanchez, F. Sole, S. Serrano

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Primitive neuroectodermal tumors (PNETs) of the central nervous system (CNS), a rare occurrence in adults, may show glial differentiation and can be misinterpreted as pure astrocytic neoplasms. Few fluorescence in situ hybridization (FISH) studies have been carried out on these tumors; isochromosome 17q was found to be the major chromosomal abnormality. We present the case of an adult in which we performed a FISH study of both the glial and neuronal components. A complex array of FISH changes, not including an isochromosome 17q were identified. ©2007 Dustri-Verlag Dr. K. Feistle.
Original languageEnglish
Pages (from-to)12-16
JournalClinical Neuropathology
Volume26
Issue number1
DOIs
Publication statusPublished - 1 Jan 2007

Keywords

  • CNS tumors
  • FISH
  • Isochromosome 17
  • PNET

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