Prevalence of sleep disorders in adults with down syndrome: A comparative study of self-reported, actigraphic, and polysomnographic findings

Sandra Giménez, Laura Videla, Sergio Romero, Bessy Benejam, Susana Clos, Susana Fernández, Maribel Martínez, Maria Carmona-Iragui, Rosa M. Antonijoan, Mercedes Mayos, Ana Fortuna, Patricia Peñacoba, Vicente Plaza, Ricardo S. Osorio, Ram A. Sharma, Ignasi Bardés, Anne Sophie Rebillat, Alberto Lleó, Rafael Blesa, Sebastian VidelaJuan Fortea

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12 Citations (Scopus)

Abstract

© 2018 American Academy of Sleep Medicine. All right reserved. Study Objectives: Sleep problems are often undetected in adults with Down syndrome (DS). Our objective was to determine the prevalence of sleep disorders in adults with DS through self-reported and objective sleep measures. Methods: We performed a community-based cross-sectional study of 54 adults with DS not referred for sleep disorders. Two polysomnography (PSG) sleep studies were performed. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI); daytime sleepiness was evaluated using the Epworth Sleepiness Scale (ESS) and the risk for the sleep apnea syndrome (OSA) was identified using the Berlin Questionnaire (BQ). Participants' sleep/wake pattern was assessed from sleep diaries and by wrist actigraphy. PSQI, ESS, and PSG measures were compared with 35 sex-, age-, and body mass index-matched patients in the control groups. Results: In PSG measures, adults with DS showed lower sleep efficiency (69 ± 17.7 versus 81.6 ± 11; P < .001), less rapid eye movement sleep (9.4 ± 5.8 versus 19.4 ± 5.1; P < .001), a higher prevalence of OSA (78% versus 14%; P < .001), and a higher apnea-hypopnea index (23.5 ± 24.5 versus 3.8 ± 10.5; P < .001) than patients in the control group. In the DS group, the questionnaires (mean PSQI 3.7 ± 2.9; mean ESS 6.3 ± 4.5 and mean BQ 1 ± 0) did not reflect the sleep disturbances detected on the PSG. Actigraphy data recorded daytime sleep that was not self-reported (118.2 ± 104.2 minutes). Conclusions: Adults with DS show severe sleep disruption and a high prevalence of OSA, undetected by self-reported sleep measures. Actigraphy, PSG, and validated simplified devices for screening OSA should be routinely recommended for this population because treatment of sleep disorders can contribute to healthy aging.
Original languageEnglish
Pages (from-to)1725-1733
JournalJournal of Clinical Sleep Medicine
Volume14
DOIs
Publication statusPublished - 15 Oct 2018

Keywords

  • Actigraphy
  • Aging
  • Down syndrome
  • Obstructive sleep apnea
  • Polysomnography
  • Self-reported sleep quality
  • Sleep disruption

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    Giménez, S., Videla, L., Romero, S., Benejam, B., Clos, S., Fernández, S., Martínez, M., Carmona-Iragui, M., Antonijoan, R. M., Mayos, M., Fortuna, A., Peñacoba, P., Plaza, V., Osorio, R. S., Sharma, R. A., Bardés, I., Rebillat, A. S., Lleó, A., Blesa, R., ... Fortea, J. (2018). Prevalence of sleep disorders in adults with down syndrome: A comparative study of self-reported, actigraphic, and polysomnographic findings. Journal of Clinical Sleep Medicine, 14, 1725-1733. https://doi.org/10.5664/jcsm.7382