Prevalence of severe esophagitis in Spain. Results of the PRESS study (Prevalence and risk factors for esophagitis in Spain: A cross-sectional study)

Núria Piqué, Marta Ponce, Vicente Garrigues, Luis Rodrigo, Félix Calvo, Carlos Martín De Argila, Fernando Borda, Antonio Naranjo, Javier Alcedo, María José Soria, Enrique Rey, Luis Bujanda, Javier P. Gisbert, David Suarez, Xavier Calvet, Julio Ponce

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)


© Author(s) 2016. Background: The current prevalence of esophagitis in southern Europe is unknown. In addition, the risk factors for reflux esophagitis are not fully understood. Objective: The objective of this article is to assess the prevalence and risk factors for esophagitis in Spain. Methods: A prospective, observational, cross-sectional, multicenter study (PRESS study) was conducted among 31 gastrointestinal endoscopy units throughout Spain. A total of 1361 patients undergoing upper gastrointestinal endoscopy were enrolled. Sociodemographic, clinical and treatment data were recorded. Results: A total of 95% of patients were Caucasian and 52% were male (mean age: 53±17 years). The most frequent symptoms prompting endoscopy were heartburn (40%), regurgitation (26%) and dysphagia (15%). Fifty-four percent of patients undergoing endoscopy were receiving proton pump inhibitor (PPI) treatment. Esophagitis (mainly mild-moderate) was present in 154 (12.4%) patients. The severe form was recorded in only 11 (0.8%) patients. Multivariate analysis results indicated that the likelihood of esophagitis was higher in men (OR=1.91, 95% CI=1.31–2.78), in patients with high GERDQ scores (OR=1.256, 95% CI=1.176–1.343), weight increase (OR=1.014, 95% CI=1.003–1.025) and high alcohol consumption (OR=2.49, 95% CI=1.16–5.36). Conclusion: Severe esophagitis is a rare finding in the Spanish population. Male gender, high GERD-Q score, weight increase and high alcohol consumption are main risk factors for its appearance.
Original languageEnglish
Pages (from-to)229-235
JournalUnited European Gastroenterology Journal
Publication statusPublished - 1 Jan 2016


  • Barrett’s esophagus
  • Endoscopy
  • Gastro-esophageal reflux disease (GERD)
  • Gastrointestinal symptoms
  • Hiatal hernia
  • Nonsteroidal anti-inflammatory drugs (NSAID)
  • Questionnaires
  • Severe esophagitis


Dive into the research topics of 'Prevalence of severe esophagitis in Spain. Results of the PRESS study (Prevalence and risk factors for esophagitis in Spain: A cross-sectional study)'. Together they form a unique fingerprint.

Cite this