Abstract
Three new bis(cyclobutane) β-dipeptides have been synthesized from appropriate derivatives of cis- and trans-2-aminocyclobutane-1-carboxylic acid, respectively. The predominance of eight-membered hydrogen-bonded rings has been manifested for (trans,trans)- and (trans,cis)-β- dipeptides while the formation of six-membered rings is preferred for the (cis,trans)- β-dipeptide similarly to the previously described (cis,cis)-diastereomer. © 2009 American Chemical Society.
Original language | English |
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Pages (from-to) | 2301-2304 |
Journal | Organic Letters |
Volume | 11 |
Issue number | 11 |
DOIs | |
Publication status | Published - 4 Jun 2009 |